PrEP Use and STIs are not Associated Longitudinally in a Cohort Study of YMSM/TGW in Chicago Ethan Morgan, PhD Institute for Sexual and Gender Minority.

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PrEP Use and STIs are not Associated Longitudinally in a Cohort Study of YMSM/TGW in Chicago Ethan Morgan, PhD Institute for Sexual and Gender Minority Health and Wellbeing Northwestern University

No Disclosures to Declare Maybe keep and say preliminary

Methods Goal: To understand whether pre-exposure prophylaxis (PrEP) users are at increased risk for rectal sexually transmitted infections (STIs). Sample: Ongoing longitudinal cohort study of young men who have sex with men and transgender women (YMSM/TGW) in Chicago, aged 16-29 (N~1100, n=744) Analyses: Longitudinal multilevel lagged regression models Mediation models considering the potential pathway: PrEP use → Condomless Anal Sex (CAS) → Rectal STIs Maybe keep and say preliminary

Proportion of participants testing positive for any rectal STI Pre-PrEP Uptake No PrEP Post-PrEP Uptake

Sample: PrEP use: 32.9%, RCT-NG: 16.8%, RCT-CT: 23.0% Results Sample: PrEP use: 32.9%, RCT-NG: 16.8%, RCT-CT: 23.0% Longitudinal lagged models: No significant relationship between PrEP use and risk of rectal STI Similar results with varying PrEP use patterns Mediation models: PrEP use prospectively predicted increase likelihood of CAS, but CAS did not predict rectal STIs

Acknowledgements NIH/NIDA U01DA036939 F32DA046313 Co-Authors Dr. Brian Mustanski Dr. Michael Newcomb Dr. Richard D’Aquila Dr. Christina Dyar