miR-100 suppresses bladder cancer cell growth in vitro and in vivo.

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Volume 342, Issue 1, Pages (January 2014)

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miR-100 suppresses bladder cancer cell growth in vitro and in vivo. miR-100 suppresses bladder cancer cell growth in vitro and in vivo. A, top, the effect of miR-100 on cell proliferation of miR-100–overexpressing cells (EJ and 5637, lentivirus infected at MOI = 40); bottom, inhibition of miR-100 increased the growth ratio of the bladder cancer cell lines (J82 and HT-1376, oligonucleotide transfected at 150 nmol/L). B, the effect of miR-100 on colony formation of bladder cancer cells (EJ and 5637). Representative results of colony formation of lenti-miR-100 (up), lenti-vector (bottom)-transfected 5637, and EJ cells. C, the effect of miR-100 on tumor formation in 2 nude mouse xenograft models. Lenti-miR-100- or vector-transfected EJ cells (1 × 107) were injected s.c. into the right flank of a nude mouse (top) or intravesically of a nude mouse (bottom). Left, lenti-miR-100 group; right, lenti-vector group. D, the effect of intratumoral injection of cholesterol-conjugated agomir-100 on tumor growth in another nude mouse xenograft model. *, P < 0.05; **, P < 0.01. Chuanliang Xu et al. Mol Cancer Ther 2013;12:207-219 ©2013 by American Association for Cancer Research