A novel multi-channeled neonatal patient Y-piece device (AFECTAIR) developed as part of an aerosolized lung surfactant administration system to be used.

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The patient is being ventilated with 2 types of breaths.
The changes in peak flow and inspiratory time between a minimum rise time (first 2 breaths) and a maximum rise time (last 2 breaths), with the Servo-i.
Airway pressure and flow waveforms during constant flow volume control ventilation, illustrating the effect of an end-inspiratory breath-hold. Airway pressure.
Example ventilator screen during nasal neurally adjusted ventilatory assist in a premature neonate (23 weeks gestational age, 560 g) with respiratory distress.
Air flow during ventilator-supported speech production.
Lung CT images were obtained while tracing the curve in static conditions. Lung CT images were obtained while tracing the curve in static conditions. Note.
Schematic illustration of upper airway anatomical dead space volume (VD) during unidirectional breathing. Schematic illustration of upper airway anatomical.
Lung simulator diagram of airway pressure release ventilation (APRV): volume (yellow), lung pressure (white), and flow (orange)/time curve. Lung simulator.
HomeLOX liquid oxygen system, which creates oxygen from a concentrator and refrigerates the concentrator gas to a liquid state, which is stored in a small.
The Spectrum mask incorporates the leak port into the circuit, whereas the Mirage mask incorporates the leak port into the mask. The Spectrum mask incorporates.
Cuff-pressure changes after the addition of 5 mL and 10 mL of air into the cuff of 3 artificial airways, after initial baseline of 30 cm H2O established.
Even though this patient is undergoing positive-pressure mechanical ventilation, the first 4 breaths have a relatively negative pressure (ie, pressure.
A: Pressure (green) and volume (black)/time curve in airway pressure release ventilation (APRV). A: Pressure (green) and volume (black)/time curve in airway.
An example of delayed cycling during pressure-support ventilation of a patient with COPD, on a Puritan Bennett 7200 ventilator, which has a flow-termination.
The third breath has a negative deflection (ie, below PEEP) at the end of the mechanical breath (arrow A) associated with a flow increase (arrow B), indicating.
Example airway pressure and rib-cage impedance in a premature infant supported with the biphasic mode of SiPAP (“sigh” positive airway pressure) from the.
Simulated screenshot of flow starvation in volume control continuous mandatory ventilation. Simulated screenshot of flow starvation in volume control continuous.
Characteristics of a pressure-supported breath.
The peak flows (60 L/min) and flow patterns are the same for all the breaths. The peak flows (60 L/min) and flow patterns are the same for all the breaths.
During this tracing of 30 seconds, the ventilator displays that the patient rate is 16 breaths/min. During this tracing of 30 seconds, the ventilator displays.
A: Machine-triggered intermittent mandatory ventilation (IMV) with inadequate patient triggering of mandatory breaths. A: Machine-triggered intermittent.
Interactions among clinician, patient, and ventilator.
Trigger and synchronization windows.
Typical pressure-time curves during forced expiration against an occluded airway in cystic fibrosis (CF) patients and healthy controls. Typical pressure-time.
Pressure, flow, volume, and electrical activity of the diaphragm (EAdi) waveforms from a patient on pressure support ventilation, and the presumed pressure.
In this tracing of 30 seconds, 4 breaths are ineffectively triggered (arrows IT) and 7 are effectively triggered. In this tracing of 30 seconds, 4 breaths.
A 2-min recording showing periodic breathing, stable delivered pressure, and fluctuating oxygen saturation in a premature neonate supported by nasal intermittent.
Histology of lung tissue from preterm lambs ventilated for 3 days with invasive intermittent mandatory ventilation (IMV) (A and C) or noninvasively with.
This tracing depicts 30 seconds of information.
Graphic representation of a dynamic airway pressure scalar during volume control ventilation with a constant inspiratory flow. Graphic representation of.
Work rate as a function of pressurization rate and cycling-off threshold, during pressure-support ventilation of (A) patients with acute lung injury (ALI),
Effect of respiratory mechanics on cycling of pressure support from inhalation to exhalation. Effect of respiratory mechanics on cycling of pressure support.
Flow, esophageal pressure, airway pressure, and transpulmonary pressure can be used to calculate respiratory system compliance, chest-wall compliance,
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Blom speech cannula. Blom speech cannula. Inspiratory pressure opens the flap valve and closes (expands) the bubble valve, sealing the fenestration so.
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Electrical impedance tomographic (EIT) images are created using a series of electrodes placed across the chest, each of which send and receive electrical.
The Boussignac continuous positive airway pressure (CPAP) is a small plastic cylinder that attaches to a face mask. The Boussignac continuous positive.
Control circuit for set-point or dual targeting schemes.
Gamma camera scans showing posterior lung images of 4 adult patients with cystic fibrosis following inhalation of an aerosol containing the radioisotope.
Assembly used to convert a standard ventilator to an intermittent mandatory ventilation circuit. Assembly used to convert a standard ventilator to an intermittent.
Control circuit for a servo targeting scheme (eg, Proportional Assist Ventilation). Control circuit for a servo targeting scheme (eg, Proportional Assist.
Intra-device comparison of albuterol captured at the end of the endotracheal tube (lung dose). Intra-device comparison of albuterol captured at the end.
This figure is an example of a 14-year-old child with obstructive lung disease due to cystic fibrosis. This figure is an example of a 14-year-old child.
Venn diagram illustrating how the mode taxonomy can be viewed in terms of discriminating features and defining features. Venn diagram illustrating how.
Total drug dose by device and condition while delivering 1 mL of ribavirin (5 min for the small-particle aerosol generator [SPAG] or 2 min for the vibrating.
Graphical representation of the locations where spontaneous breaths may occur during the airway pressure (Paw) release ventilation ventilatory cycle. Graphical.
Mean inspiratory work of breathing during assisted breaths and spontaneous breaths across the spectrum of ventilatory support continuous mandatory ventilation.
Calculated negative pressure developed in the lung plotted against the outside diameter of the suction catheter to the inside diameter of the airway. Calculated.
Flow, airway pressure, and transversus abdominis electromyogram (EMG) waveforms from a mechanically ventilated patient with COPD receiving pressure-support.
Components of a patient-triggered mechanical breath.
FEV1 and FVC for the control group (without noninvasive ventilation [NIV]), NIV with an inspiratory pressure (IPAP) of 15 cm H2O and expiratory pressure.
Determinants of patient-ventilator interaction.
Airway pressure and flow graphics illustrate delayed cycling.
Choosing inhaler therapy for patients with stable COPD based on the Global Initiative for Chronic Obstructive Lung Disease grouping. Choosing inhaler therapy.
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) ABCD scheme for classifying patients with COPD with separate appraisal of air-flow limitation.
A: Work of breathing before and after nebulized terbutaline delivered via standard nebulization method versus delivered during continuous positive airway.
The changes in peak flow and inspiratory time between a minimum rise time (first 2 breaths) and a maximum rise time (last 2 breaths), with the Servo-i.
Experimental setup. Experimental setup. Each tested ventilator was connected to the TTL test lung via a ventilator circuit. An oxygen analyzer, a pressure.
FEV1/FVC ratios for females in the National Health and Nutrition Examination Survey III study are plotted against their age. FEV1/FVC ratios for females.
Delivery efficiency with different devices, ventilator positions, and ventilator settings. Delivery efficiency with different devices, ventilator positions,
Efficiency of aerosol bronchodilator delivery during continuous high-flow system at different CPAP and flow levels. Efficiency of aerosol bronchodilator.
Enhancing flow synchrony with a variable flow, pressure-targeted breath. Enhancing flow synchrony with a variable flow, pressure-targeted breath. In the.
Difference between mid-frequency ventilation (MFV), volume control continuous mandatory ventilation (VC-CMV), and pressure control CMV (PC-CMV) when frequency.
A: Comparison of pediatric lung transplant survival between different age groups. A: Comparison of pediatric lung transplant survival between different.
Average drug doses in the peripheral lung, central lung, and extrathoracic airway; residual drug left in the device; and residual drug that was exhaled.
Basic setup for high-flow nasal cannula oxygen delivery.
Fentenyl and lorazepam use for the first 5 d of ventilatory support are presented. Fentenyl and lorazepam use for the first 5 d of ventilatory support.
Setup of the BiPAP Synchrony with an inspiratory filter and single-limb passive circuit, with the filter placed over the fixed leak to collect aerosol.
Presentation transcript:

A novel multi-channeled neonatal patient Y-piece device (AFECTAIR) developed as part of an aerosolized lung surfactant administration system to be used with AEROSURF (lucinactant), a form of inhaled lung surfactant. A novel multi-channeled neonatal patient Y-piece device (AFECTAIR) developed as part of an aerosolized lung surfactant administration system to be used with AEROSURF (lucinactant), a form of inhaled lung surfactant. The AFECTAIR uses fluidic principles to effectively decouple ventilator bias flow from nebulizer flow pathways and provide a more direct route into the airway. Not only does this provide less drug delivered into the expiratory circuit, but by providing a more direct route and hence laminar flow to the airway, less drug impaction may occur in the artificial airways. IMV = intermittent mandatory ventilation. Courtesy Discovery Labs. Robert M DiBlasi Respir Care 2015;60:894-916 (c) 2012 by Daedalus Enterprises, Inc.