Acute phosphate nephropathy

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Presentation transcript:

Acute phosphate nephropathy Alexander K. Rocuts, Sushrut S. Waikar, Mariam P. Alexander, Helmut G. Rennke, Ajay K. Singh Kidney International Volume 75, Issue 9, Pages 987-991 (May 2009) DOI: 10.1038/ki.2008.293 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Renal biopsy findings in acute phospho-nephropathy. (a) Coarse basophilic, rounded deposits of calcium phosphate are present within the lumina of tubules (hematoxylin–eosin, high-power field, original magnification × 40). (b) The widespread multifocal nature of the intratubular calcium–phosphate deposits is best illustrated with the von Kossa stain (von Kossa stain, high-power field, original magnification × 60). (c) Glomeruli displaying mesangial sclerosis with the formation of distinctive acellular nodules (periodic acid-Schiff stain, high-power field, original magnification × 40). Kidney International 2009 75, 987-991DOI: (10.1038/ki.2008.293) Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 2 Acute phosphate nephropathy progression after OSPS exposure. Graph shows the trends of estimated glomerular filtration rate, serum calcium and phosphate, and total urine protein-to-creatinine ratio at baseline and up to 5 months after exposure to OSPS. The arrow marks the time when the patient was exposed to OSPS. Kidney International 2009 75, 987-991DOI: (10.1038/ki.2008.293) Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 3 Fleet Phospho-soda warning in the hospital clinical information system. Kidney International 2009 75, 987-991DOI: (10.1038/ki.2008.293) Copyright © 2009 International Society of Nephrology Terms and Conditions