Circulating leukocytes are undetectable in blood vessels of solid tumors in RIP1-Tag2 mice even after IL-15/IL-15Rα complex treatment. Circulating leukocytes.

Slides:

Advertisements

Similar presentations

AF647-RIS is internalized by TAMs in vivo.

Advertisements

Anti–4-1BB/PD-1 combination enriched CD8+ T cells in TILs

CD4+ICOS+IL-4+ TFH cells are sparse in human SLOs.

Histopathologic features (all images at ×10 magnification).

Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.

TIE2hi/VEGFAhi TEMs are present in the TMEM

Effects of SC144 on in vivo ovarian tumor.

H31m1-PDL1 cells form progressively growing tumors in WT mice.

Representative multiplex immunofluorescence image of synovial sarcoma with increased PD-L1/PD-1/CD8 cell densities at the tumor-invasive margin demonstrating.

Fig. 5. Vascularization of human liver seed grafts.

Macrophage-specific ablation of Vegfa in PyMT implant tumors blocks blood vessel permeability and tumor cell intravasation at the TMEM. A and C, immunofluorescence.

XL184 effects on RIP-Tag2 tumor invasion and epithelial/mesenchymal markers. XL184 effects on RIP-Tag2 tumor invasion and epithelial/mesenchymal markers.

IL-27–eGFP is highly expressed by cDC1 cells and Ly6Chi monocytes after vaccine adjuvant administration. IL-27–eGFP is highly expressed by cDC1 cells and.

Pten deficiency induces strong stromal reaction with immune cell infiltration and promotes the development of invasive and metastatic pancreatic tumors.

Inhibition of VEGFA or macrophage-specific ablation of Vegfa from TIE2hi/VEGFAhi TMEM macrophages reduces vascular permeability and tumor cell intravasation.

Anti-CD20 CAR exPBNK significantly inhibit growth of Raji cells in xenografted mice. Anti-CD20 CAR exPBNK significantly inhibit growth of Raji cells in.

Existence of a nuclear NFATc1–STAT3 complex in pancreatic cancer.

mpJX-594 effects on tumor burden and leukocyte influx.

Protection from autoimmunity is not due to the expansion of Treg subsets. Protection from autoimmunity is not due to the expansion of Treg subsets. (A.

B cells infiltrate mouse and human pancreatic neoplasia and promote growth of KrasG12D-PDEC in vivo. B cells infiltrate mouse and human pancreatic neoplasia.

Volume 8, Issue 3, Pages (August 2014)

ILK knockdown decreases mTOR signaling in PKD kidneys.

Instigating, noninstigating, and responding human tumor specimens.

Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and increased T-cell activation. Socs1 KD tumors exhibit a more T-cell–inflamed phenotype and.

Socs1 KD tumors exhibit a more T cell–inflamed phenotype and increased CD8+ T cell activation. Socs1 KD tumors exhibit a more T cell–inflamed phenotype.

PD-1, but not PD-L1, expressed by the BDC2

Expression of p110γ isoform in macrophages promotes tumor growth and angiogenesis. Expression of p110γ isoform in macrophages promotes tumor growth and.

Insulitis is reduced in CT-treated RIP-LCMV-GP mice.

LacZ staining and immunofluorescence analyses of the uterus of different genotypes. LacZ staining and immunofluorescence analyses of the uterus of different.

Effect of mitomycin C and bortezomib on the growth of LS174T intraperitoneal tumors. Effect of mitomycin C and bortezomib on the growth of LS174T intraperitoneal.

S-Affs colocalize with SUMO in mammalian cells.

Effects of PS-341 on apoptosis in orthotopic human pancreatic tumors.

CDCP1 colocalizes and interacts with MT1-MMP.

IL6 mRNA is not detected in metastatic prostate cancer cells.

Antigen-specific CD8+ T cells express higher levels of PD-1 in animals that received the optimized SSX2 vaccine. Antigen-specific CD8+ T cells express.

In vivo thrombosis of tumor vasculature.

A His/Pro-rich fragment of HRG is present in human tissue.

Anti-Flk-1 mAb treatment reduces vessel density in tumors.

Tumors treated with anti-Flk-1 mAb have increased tumor cell apoptosis, reduced tumor cell proliferation, and increased tumor necrosis. s.c. Tumors treated.

EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo. EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo.

5FU-induced specific activation of CD8+ T cells.

CD4+ and CD8+ TILs express surface CD137.

CDN–treated MOC1 tumors demonstrate enhanced activation of innate and antigen-specific adaptive immunity. CDN–treated MOC1 tumors demonstrate enhanced.

Expression of XCR1 in normal ovarian surface epithelium and the IOSE and borderline EOC cell lines. Expression of XCR1 in normal ovarian surface epithelium.

Fig. 5. Vascularization of human liver seed grafts.

Ki-67 expression in M31- and H3-treated tumors (A) and respective Ki-67 labeling indices in the two groups of tumors (B). Ki-67 expression in M31- and.

CA-MSCs differentially secrete GM-CSF.

SY-1425 induces maturation in RARA-high AML

Ablation of Nf1 in HOXB7 lineage cells gives rise to diffuse cNF.

Establishment of MajSAT RNA–expressing mice.

In vivo demonstration of EMT in GFP-tagged tumors.

BEZ235 inhibits DNA-PK and enhances G2–M growth arrest after radiation

Immunophenotypic analysis of TILs in B16 and K1735 melanoma following combination therapy with antibodies targeting PS and PD-1. Immunophenotypic analysis.

Circulating leukocytes do not efficiently infiltrate advanced solid tumors in IL-15/IL-15Rα complex–treated RIP1-Tag2 mice. Circulating leukocytes do not.

Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex treatment. Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex.

Expression of HO-1 by the FAP+/F4/80+ tumoral macrophages.

Pomalidomide decreases fibrosis in the lesion areas of the pancreas of KC mice. Pomalidomide decreases fibrosis in the lesion areas of the pancreas of.

TAMs directly contribute to tumor hypoxia.

Specific reaction with MIB1, M30, and CD31 monoclonal antibodies in primary human cervical carcinoma before (A, C, and E) and after (B, D, and F) Tam treatment.

Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.

Cabozantinib causes significant tumor cell elimination in vivo, but modest apoptosis induction in vitro. Cabozantinib causes significant tumor cell elimination.

Leukocyte populations in normal and neoplastic breast tissues.

EGF induces HPSE nucleolar localization in human BMBC cells.

AXL-on tumors are heterogeneous for AXL expression and EdU incorporation. AXL-on tumors are heterogeneous for AXL expression and EdU incorporation. A,

Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells. Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells.

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

CD36 expression in tissue adjacent and distal to the tumor.

PEGPH20 depletes HA and decompresses intratumoral vessels.

Spontaneous PD in DRB1*04:01 mice.

Presentation transcript:

Circulating leukocytes are undetectable in blood vessels of solid tumors in RIP1-Tag2 mice even after IL-15/IL-15Rα complex treatment. Circulating leukocytes are undetectable in blood vessels of solid tumors in RIP1-Tag2 mice even after IL-15/IL-15Rα complex treatment. Histologic analysis of blood vessels in parenchymal tissues and tumors of IL-15/IL-15Rα complex treatment and control RIP1-Tag2 mice. A and B, left, organs were fixed and processed for H&E staining. Images show representative histology of liver, kidney, exocrine pancreas, and pancreatic tumors in control and IL-15/IL-15Rα complex–treated RIP1-Tag2 mice. Right, quantification of leukocytes in blood vessels of liver, kidney, exocrine pancreas, and pancreatic tumors in control and IL-15/IL-15Rα complex–treated RIP1-Tag2 mice from two independent experiments (n = 7 individual mice per condition). C, immunofluorescence microscopic analysis of CD8+ T cells in tumors of IL-15/IL-15Rα complex–treated and control RIP1-Tag2 mice. Tumors were excised 48 h after treatment with IL-15/IL-15Rα complexes and frozen in OCT. Cryosections from pancreata of treated and control mice were stained with DAPI (blue) and monoclonal antibodies to CD8 (red) and the pan-blood vessel marker, CD31 (green). Left, images (×20) are representative of more than four independent experiments. Right, areas in white boxes are magnified. Mathieu Epardaud et al. Cancer Res 2008;68:2972-2983 ©2008 by American Association for Cancer Research