Bortezomib induces an NRF2 signature and NRF2 protein in tumor cells from leukemic MCL. Gene sets regulated by bortezomib (Supplementary Tables S3 and.

Slides:

Advertisements

Similar presentations

Organic solute transporter (OSTα-OSTβ) expression in human control livers and patients with stage III and IV primary biliary cirrhosis. Organic solute.

Advertisements

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Hnf4g importance in human colon cancer organoids and regulation of the Hnf4a locus Hnf4g importance in human colon cancer organoids and regulation of the.

Effects of SC144 on in vivo ovarian tumor.

Peritumoral injections of poly(I:C) induce type I IFN–dependent cytotoxic immunity and delay the growth of primary and transplanted Hgf-Cdk4R24C melanomas.

Microarray analysis of phospho-Twist1–responsive genes.

Antitumor effect of local cancer immunotherapy treatment toward distant B16F10 tumors. Antitumor effect of local cancer immunotherapy treatment toward.

Putative targets of miRNAs directly induced by p53 with down-regulated mRNA- and de novo protein synthesis or reduced de novo protein synthesis only. Putative.

K-Means clustering of protein and mRNA expression patterns after PPAR agonists treatments. k-Means clustering of protein and mRNA expression patterns after.

Changes in mRNA levels do not correlate with changes in protein levels in upf1Δ and xrn1Δ cells. Changes in mRNA levels do not correlate with changes in.

Volume 25, Issue 13, Pages e6 (December 2018)

Down-regulation of LATS1 promotes the formation of tumors enriched in basal-like features. Down-regulation of LATS1 promotes the formation of tumors enriched.

Existence of a nuclear NFATc1–STAT3 complex in pancreatic cancer.

Fig. 2. Ex vivo inducible knockout of PDCD2 in ESCs results in loss of S phase entry and increased p53.(A) Growth curve of inducible knockout and WT ESCs.

Smad3-KO adipose tissues have increased FA uptake and β-oxidation.

Fig. 1. DEL-1 is expressed by human and mouse osteoclasts.

Distinct molecular and clinical correlates of H3F3A mutation subgroups

Fig. 6 RUNX/CBFB interaction inhibitor, Ro5-3335, significantly decreases mouse neurofibroma growth in vivo. RUNX/CBFB interaction inhibitor, Ro5-3335,

Increased CCL5 expression, infiltration of Treg cells, and apoptosis of CD8+ T cells in human colorectal tissues. Increased CCL5 expression, infiltration.

Leukemic blasts express a “hypoxia signature

Integrated mRNA and microRNA expression and DNA methylation clusters.

Protein expression profile in a dasatinib-resistant cell line.

SATB2-AS1 repressed Snail transcription depending on SATB2-mediated recruitment of HDAC1. SATB2-AS1 repressed Snail transcription depending on SATB2-mediated.

Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.

CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated with a longer survival. CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated.

EGFR and cetuximab sensitivity of SCCUAT

Ki-67 expression is determined by the cell-cycle stage.

The effect of IAA on tumor growth in an SK-MEL-28 xenograft model.

MiR-200c is a PI3K–AKT signaling pathway regulator in CRC

EN1-associated chromatin complexes in breast cancer cells.

High-throughput siRNA screening results and corresponding patient gene expression data for PP2A subunits. High-throughput siRNA screening results and corresponding.

MRNA expression IL-1α, IL-1β, IL-1Ra, IL-1RtI, ER α, ER β, and PR was analyzed by RT-PCR as described in “Materials and Methods.” Representative gel electrographies.

Molecular signatures are independent of tumor stage and grade.

In vivo tumorigenicity of MKN-1 cells with sustained suppression of HDAC2. In vivo tumorigenicity of MKN-1 cells with sustained suppression of HDAC2. A,

Transcripts enriched and depleted in NB TICs compared with SKPs and other tumor tissues. Transcripts enriched and depleted in NB TICs compared with SKPs.

Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. A, bar.

Dysregulated NF-κB activation in Il1r8+/+/lpr and Il1r8−/−/lpr mice.

Treatment with DZNep depletes expression of PRC2 proteins EZH2, SUZ12, and associated 3MeK27H3 levels in cultured human MCL cells. Treatment with DZNep.

Nested RT-PCR of Mammaglobin and CK19 mRNA in plasma and circulating cells of controls (C) and patients (T) with breast cancer. Nested RT-PCR of Mammaglobin.

SY-1425 induces maturation in RARA-high AML

C-MYC overexpression or growth in serum-containing media induces EMT in HBEC3p53,KRAS. c-MYC overexpression or growth in serum-containing media induces.

FGFR1 is dominantly expressed in mesenchymal-like KRAS-mutant lung cancer cell lines. FGFR1 is dominantly expressed in mesenchymal-like KRAS-mutant lung.

ODC protein expression in paired benign and cancer tissue obtained from patients with PCA. The protein expression was measured by immunoblot analysis in.

MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E. MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Expression.

Molecular definitions of lung adenocarcinoma subtypes.

SAHA blocks IR-induced increase of RAD51 protein in MM cells.

The effects of AZD1775 and olaparib on DNA damage response signaling.

Increased expression of angiogenic factors and inflammatory cytokines in mice exposed to hypoxia. Increased expression of angiogenic factors and inflammatory.

MGA271 exhibits potent in vivo antitumor activity toward tumor cell carcinoma xenografts. MGA271 exhibits potent in vivo antitumor activity toward tumor.

Targeting GAPLINC decreased CD44 expression and tumor growth in vivo.

Inhibition of CD20 mRNA expression by ibrutinib correlates with reduced NF-κB activity. Inhibition of CD20 mRNA expression by ibrutinib correlates with.

Validation of NAA's cancer specificity in lung cancer.

Effect of MIF siRNA on the production of MMP-13 induced by LPA

Establishment of HeLa/rtTAA/TRE-N1-IC cell line.

Increased growth factor receptor expression in lungs and tumors of hypoxic mice. Increased growth factor receptor expression in lungs and tumors of hypoxic.

Effect of dexamethasone on PCDGF/GP88 mRNA and protein expressions and effect of PCDGF/GP88 on dexamethasone-induced cell death. Effect of dexamethasone.

Defining the eTME genes.

Expression of chemokine receptors in A-498 cell line.

Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105.

CPGL is a growth suppressor in pancreatic cancer cell lines.

IL-1β expression is increased in MM cell lines by the co-culture with platelets in vitro. IL-1β expression is increased in MM cell lines by the co-culture.

Mechanism by which flavopiridol induces cell cycle arrest and apoptosis in rhabdoid tumor cells. Mechanism by which flavopiridol induces cell cycle arrest.

Correlations between APOBEC expression and immune cell markers across 22 cancer types. Correlations between APOBEC expression and immune cell markers across.

Regulation of NUAK1 by NRF2 and ROS

Gene expression heatmap of non–T-cell-inflamed, intermediate, and T-cell–inflamed testicular germ cell tumors from TCGA. Genes are on the row, and samples.

Highly metastatic PDAC cells have a unique gene signature, which is not preserved in metastases but predicts poor patient outcome. Highly metastatic PDAC.

JQ1 selectively ablates PAX3–FOXO1-driven transcription and BRD4 interaction. JQ1 selectively ablates PAX3–FOXO1-driven transcription and BRD4 interaction.

CREB1 binds at the proximal region of the TGFB2 promoter and induces its transcriptional activation. CREB1 binds at the proximal region of the TGFB2 promoter.

Presentation transcript:

Bortezomib induces an NRF2 signature and NRF2 protein in tumor cells from leukemic MCL. Gene sets regulated by bortezomib (Supplementary Tables S3 and S4) in tumor cells in vivo at 96 hours are summarized. Bortezomib induces an NRF2 signature and NRF2 protein in tumor cells from leukemic MCL. Gene sets regulated by bortezomib (Supplementary Tables S3 and S4) in tumor cells in vivo at 96 hours are summarized. A, the average fold changes in expression of the most significantly enriched genes for each gene set (leading edge genes) are shown: Left, motif-based gene sets, Right, curated gene sets. Asterisk indicates P-value of the comparison between the two groups of patients (Student's t-test). B, heatmap of fold change mRNA expression of proteasome subunits in response to bortezomib at 96 hours. Immunoblot of β5 subunit (PSMB5) protein expression in CD19-selected tumor cells. p97 was used as loading control. C, heatmap of the fold-change expression of experimentally validated NRF2 signature genes (36) ranked by the average fold change in MCL1 and MCL3 at 96 hours of bortezomib treatment in vivo. D, the averaged fold-change mRNA expression of the NRF2 signature genes is shown (P = 0.034, Student's t-test). Immunoblot of NRF2 protein expression in CD19-selected tumor cells before and 96 hours of bortezomib treatment in vivo. p97 was used as loading control. Marc A. Weniger et al. Clin Cancer Res 2011;17:5101-5112 ©2011 by American Association for Cancer Research