Fig. 1 Social transfer of CFA and morphine withdrawal–induced pain.

Slides:

Advertisements

Similar presentations

Fig. 2. The expression of pKr-2 in the substantia nigra (SN) of patients with Parkinson's disease (PD). (A, B) Western blot analysis for pKr-1-2 and pKr-2,

Advertisements

Biological Psychiatry

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat D.R. Sagar, L. Nwosu, D.A. Walsh,

O. Moriarty, L. Harrington, S. Beggs, S.M. Walker

Low back pain and disc degeneration are decreased following chronic toll-like receptor 4 inhibition in a mouse model Emerson Krock, Magali Millecamps,

Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat S. Kelly, K.L. Dobson, J. Harris Osteoarthritis.

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

Levels of cytokines and chemokines in TPL-treated (from ED2) and control (H2O) mice at midgestation (ED10). Levels of cytokines and chemokines in TPL-treated.

Nitrous oxide (N2O) reduces postoperative opioid-induced hyperalgesia after remifentanil–propofol anaesthesia in humans G. Echevarría, F. Elgueta, C.

Up‐ or down‐regulation of microRNAs (miRNAs) in sensory neurons of the dorsal root ganglia (DRG) in a model of bone metastases pain A.Increase in frequency.

Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior.

Conditioned pain modulation identifies altered sensitivity in extremely preterm young adult males and females S.M. Walker, H. O'Reilly, J. Beckmann,

In vitro and in vivo validation of Clcn3 as a miR‐1a‐3p target gene and its functional contribution to tumor‐induced mechanical hypersensitivity in the.

Intra-articular nerve growth factor regulates development, but not maintenance, of injury-induced facet joint pain & spinal neuronal hypersensitivity

Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Surface renderings of the brain activation showing significant activation in the general mixed design ANOVA for the interaction between all three factors,

Intraoperative naloxone reduces remifentanil-induced postoperative hyperalgesia but not pain: a randomized controlled trial C.-H. Koo, S. Yoon, B.-R.

Adult neurogenesis ablation in the vDG but not in the dDG blocked the analgesic effect of EE-VEx in chronic inflammatory pain. Adult neurogenesis ablation.

Ryan A. Mischel, William L. Dewey, Hamid I. Akbarali

(A and B) Changes in the apnoea hypopnoea index (AHI) and 3% oxygen desaturation index (ODI) from baseline to treatment titration and 3 months of therapy:

Volume 18, Issue 12, Pages (March 2017)

N.A. Manering, T. Reuter, H. Ihmsen, D.C. Yeomans, A. Tzabazis

MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical.

Comparison of network robustness measures over a larger time window

Fig. 6 In utero injection of inflammatory cytokines or adoptive transfer of activated T cells leads to pregnancy loss. In utero injection of inflammatory.

Fig. 2 Social transfer of alcohol withdrawal–induced mechanical sensitivity to nearby water-drinking controls. Social transfer of alcohol withdrawal–induced.

Experimental design for serological analyses.

Fig. 4 The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling. The extracellular domain of sortilin is sufficient for BDNF/TrkB signaling.

Fig. 3 Sortilin deletion unmasks NTSR2 signaling.

The rain-fed maize growing niche in the southwestern United States, A

Influence on chronic morphine on pain.

Fig. 4 Whisker deprivation–induced remapping is stable beyond the deprivation period. Whisker deprivation–induced remapping is stable beyond the deprivation.

Fig. 1 KCC2 down-regulation is prevented in sortilin-deficient mice.

Fig. 2 Exercise training potentiates synaptic transmissions via mTOR activation. Exercise training potentiates synaptic transmissions via mTOR activation.

Fig. 4 The activation of mTOR is necessary for exercise-enhanced axonal myelination in the CC region. The activation of mTOR is necessary for exercise-enhanced.

The thickness of the subchondral bone plate for healthy subjects and patients with osteoarthritis (OA). The thickness of the subchondral bone plate for.

Treating ischemia via recruitment of antigen-specific T cells

Fig. 3 Treating vaccinated mice with OVA-releasing scaffolds enhances angiogenesis and muscle regeneration following ischemic injury. Treating vaccinated.

Fig. 4 Reconstitution of MCs in KitW-sh/W-sh mice increases IL-10+ Breg cells and suppresses the CHS response. Reconstitution of MCs in KitW-sh/W-sh mice.

by Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Xudong Zhang, Anna R

PTEN inhibition unmasks the antihyperalgesic efficacy of the δR agonist SNC80. PTEN inhibition unmasks the antihyperalgesic efficacy of the δR agonist.

Fig. 4 Control analyses ensured that the relation between rotational acceleration and changes in FA does not depend on thresholds. Control analyses ensured.

NicA2-J1 prevents nicotine addiction–like behavior during withdrawal

Intra-amygdala MPEP is analgesic during bladder distention.

Fig. 3 Evolutions of freshwater transport and salinity.

by Cathryn A. Manduca, Ellen R. Iverson, Michael Luxenberg, R

Fig. 1. The HCN channel blocker ivabradine (IVA) is analgesic in a mouse model of type 1 diabetes. The HCN channel blocker ivabradine (IVA) is analgesic.

Fig. 1 OVA-releasing scaffolds concentrate OVA-specific CD4+T cells following ischemic injury. OVA-releasing scaffolds concentrate OVA-specific CD4+T cells.

Fig. 4 Dox-CBD-SA treatment shows reduced toxicity.

Fig. 3 Echocardiographic analyses of cardiac function.

Optogenetically stimulated Aβ fibers induce pain-like behaviors after PNI. A, B, Withdrawal score by light (A) and paw withdrawal threshold by von Frey.

Fig. 7 FAE-20 increases hippocampal excitability and leads to more stable contextual fear memory in mice. FAE-20 increases hippocampal excitability and.

Fig. 5 Demonstrations of the saTENG for large-area energy conversion and to harvest energy, using flowing water as the electrode. Demonstrations of the.

Selective and coherent activity increases due to stimulation indicate functional distinctions between episodic memory networks by Sungshin Kim, Aneesha.

Fig. 4 Vacuum battery on the chip.

Subodh Verma et al. BTS 2018;3:

Fig. 1 Fractional coverage of the mapping method used in this study.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Changes in the plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) level from baseline to treatment titration and 3 months of therapy: full analysis.

by Andrew W. Kraft, Adam Q. Bauer, Joseph P. Culver, and Jin-Moo Lee

Fig. 6 Stabilization of hippocampal signaling over sleep.

Fig. 4 In vivo evaluation of insulin complex for type 1 diabetic mice treatment. In vivo evaluation of insulin complex for type 1 diabetic mice treatment.

Fig. 2 Bimanual motor task performance scores.

Fig. 6 NicA2-J1 prevents nicotine- and stress-induced reinstatement after extinguished nicotine intake. NicA2-J1 prevents nicotine- and stress-induced.

ATP analogs have little effect on the conformation of the 2CARD domain

Fig. 1. APP/PS1;C3 KO mice show improved cognitive flexibility (reversal) compared to APP/PS1 mice at 16 months of age. APP/PS1;C3 KO mice show improved.

Fig. 3 Social transfer occurs via alcohol withdrawal–specific olfactory cues, and this state leads to chemical and thermal hyperalgesia. Social transfer.

Fig. 3 Evaluation of PTMAO immunogenicity.

Presentation transcript:

Fig. 1 Social transfer of CFA and morphine withdrawal–induced pain. Social transfer of CFA and morphine withdrawal–induced pain. (A) Experimental timeline of experiments presented in (B) and (C). Von Frey (VF, thick orange arrows) injections of morphine/CFA (Mor/CFA, black syringes) or naloxone (NLX, green syringe). (B) Mice subjected to intraplantar CFA injection showed a robust and persistent decrease in mechanical sensitivity for all test sessions (CFA/Co-Housed; n = 8) compared to vehicle-injected mice housed in a separate room (PBS/Separate; n = 8). Vehicle-injected mice housed in the same room as CFA-injected mice (Veh/Co-Housed; n = 8) demonstrated significantly decreased mechanical thresholds compared to Veh/Separate mice during the last three test sessions. This resulted in significant differences between groups (F2,21 = 30.0, P < 0.0001) across time (F4,84 = 27.6, P < 0.0001) and a significant interaction between these variables (F8,84 = 9.1, P = 0.003) according to repeated-measures analysis of variance (ANOVA). (C) Co-Housed mice injected with either a slow-release morphine emulsion (Mor/Co-Housed/WD; n = 7) or vehicle emulsion (Veh/Co-Housed; n = 8) every other day demonstrated significant decreases in mechanical thresholds on the two test sessions compared to vehicle-injected mice housed in a separate room (Veh/Separate; n = 7). Repeated-measures ANOVA showed a significant effect of treatment (F2,19 = 7.4, P = 0.004) and a significant effect of time (F2,38 = 5.7, P = 0.006). Following a significant interaction, Bonferroni’s post hoc analyses were conducted. Differences compared to control are represented by *, and differences compared to baseline are represented by #. Mean basal responses of all groups are represented by dotted lines. Monique L. Smith et al. Sci Adv 2016;2:e1600855 Copyright © 2016, The Authors