Changes in autoantibody titers and GADA IgG1–4 subclass distribution.

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Changes in autoantibody titers and GADA IgG1–4 subclass distribution. Changes in autoantibody titers and GADA IgG1–4 subclass distribution. GADA median titers (A), GADA median fold-change from baseline (B), and IA-2A median titers (C) in 4D (n = 49, black circles), 2D (n = 49, gray circles), and placebo (n = 50, empty circles). The median GADA IgG subclass distribution is presented as a percentage of total IgG for 4D (D), 2D (E), and placebo (F). Results were expressed as cpm, and positivity of each sample was calculated by subtraction of the mean cpm value plus three times the SD obtained for the negative control. Significant differences are indicated as P values. M, months. Stina Axelsson et al. Dia Care 2013;36:3418-3424 ©2013 by American Diabetes Association