F.-Nora Vögtle, Chris Meisinger Developmental Cell

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control Lei Zhang, Fangfang Ren, Qing Zhang, Yongbin Chen,

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics Angelika S. Rambold, Sarah.

Snail1 Is a Transcriptional Effector of FGFR3 Signaling during Chondrogenesis and Achondroplasias Cristina A. de Frutos, Sonia Vega, Miguel Manzanares,

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development Xavier Morin, Yohanns Bellaïche Developmental Cell Volume.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

Extracellular Matrix Protein Anosmin Promotes Neural Crest Formation and Regulates FGF, BMP, and WNT Activities Yukinori Endo, Hiroko Ishiwata-Endo, Kenneth.

Transcription Factor Binding to a DNA Zip Code Controls Interchromosomal Clustering at the Nuclear Periphery Donna Garvey Brickner, Sara Ahmed, Lauren.

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology Andrew G. Manford, Christopher J. Stefan, Helen L. Yuan, Jason A. MacGurn,

LDL Cholesterol Recycles to the Plasma Membrane via a Rab8a-Myosin5b-Actin- Dependent Membrane Transport Route Kristiina Kanerva, Riikka-Liisa Uronen,

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila Gerasimos P. Sykiotis, Dirk Bohmann Developmental Cell Volume 14,

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes Meng-meng Fu, Jeffrey J. Nirschl, Erika L.F.

Cyclin-Dependent Kinases Control Septin Phosphorylation in Candida albicans Hyphal Development Indrajit Sinha, Yan-Ming Wang, Robin Philp, Chang-Run Li,

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Volume 22, Issue 4, Pages (April 2012)

Ras Brakes for Hippo Developmental Cell

Diversity of Polyubiquitin Chains

IRS-1: Auditing the effectiveness of mTOR inhibitors

Jan Gruber, Brian K. Kennedy Cell

Tolloid gets Sizzled Competing with Chordin

HSF1 in Translation Cancer Cell

Antagonizing ClpP: A New Power Play in Targeted Therapy for AML

MYRFs on the Move to Rewire Circuits

Peptides Signal Mitochondrial Stress

A Mitochondrial Power Play in Lymphoma

Yorkie and Scalloped: Partners in Growth Activation

Mitochondrial Fusion: Bax to the Fussure

Stressed-Out HSCs Turn Up p38α and Purine to Proliferate

The marriage of glucose and blood vessels: It isn’t all that sweet

Methed-Up FOXOs Can't In-Akt-ivate

Zhihua Liu, Michael J. Lenardo Developmental Cell

PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic

Wnt/β-Catenin Signaling: Turning the Switch

Mitochondrial Matrix Reloaded with RNA

In This Issue Cell Volume 158, Issue 5, (August 2014)

Volume 22, Issue 6, Pages (June 2012)

Primary Cilia Bend LKB1 and mTOR to Their Will

Katharine H. Wrighton, Fangyan Dai, Xin-Hua Feng Developmental Cell

Adaptive Actin Networks

Foxo1 and Foxo3 help Foxp3 Immunity

Volume 19, Issue 3, Pages (March 2014)

Intestinal Flossing Keeps Pathogens at Bay

Volume 15, Issue 2, Pages (August 2008)

A New Twist in Smad Signaling

Volume 28, Issue 5, Pages (November 2015)

Modifying Mitochondrial tRNAs: Delivering What the Cell Needs

Metabolic Connections during Apoptotic Cell Engulfment

Autophagy Determines the Path on the TRAIL to Death

Krebs Cycle Moonlights in Caspase Regulation

Mitochondrial Sterol Oxidation Marks the Spot

Volume 22, Issue 4, Pages (April 2012)

Chaperoning through the Mitochondrial Intermembrane Space

Mitotic Chromosomes: Not So Silent After All

CDK Inhibitors: Cell Cycle Regulators and Beyond

Masako Tamada, Dene L. Farrell, Jennifer A. Zallen

Proteins in Plant Brassinosteroid Signaling

HSC Fate Is Tethered to Mitochondria

Linking DNA Damage, NAD+/SIRT1, and Aging

A Futile Battle? Protein Quality Control and the Stress of Aging

Increasing Freezing Tolerance: Kinase Regulation of ICE1

Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress

Brushed Aside and Silenced

Ras Brakes for Hippo Developmental Cell

Presentation transcript:

Sensing Mitochondrial Homeostasis: the Protein Import Machinery Takes Control F.-Nora Vögtle, Chris Meisinger Developmental Cell Volume 23, Issue 2, Pages 234-236 (August 2012) DOI: 10.1016/j.devcel.2012.07.018 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Sensing Mitochondrial (Dys)function at the Protein Import Machinery (A) In healthy mitochondria, ATFS-1 is imported via the presequence pathway after rapid degradation by the matrix protease Lon. Δψ, membrane potential; MPP, mitochondrial presequence peptidase. (B) In stressed mitochondria, ATFS-1 import is inhibited, thereby favoring nuclear translocation where it activates transcription of stress response genes. P, phosphorylation. Developmental Cell 2012 23, 234-236DOI: (10.1016/j.devcel.2012.07.018) Copyright © 2012 Elsevier Inc. Terms and Conditions