Fig. 4 Chromatin is a disordered chain that has diameters between 5 and 24 nm and is packed together at different concentration densities in interphase.

Slides:

Advertisements

Similar presentations

ChromEMT reveals the in situ chromatin ultrastructure, 3D packing, and organization of DNA. ChromEMT reveals the in situ chromatin ultrastructure, 3D packing,

Advertisements

Three different types of transfer functions with a codomain of [0,1].

Workspace comparison of Delta robots.

Ex vivo testing of the soft robotic devices.

Distribution of the number of collisions and the average closest-neighbor distance as a function of communication range and delay. Distribution of the.

Fig. 7 Correlation of NHP and human ISGs.

Fig. 1 Biomass over time of C3 grasses and C4 grasses at ambient and elevated CO2. Biomass over time of C3 grasses and C4 grasses at ambient and elevated.

In vivo tracking of PD-L1+NCMs in the microcirculation.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Fig. 2 Adhesion of water on hot repellent materials.

Translation of a spherical object.

Fig. 1 Pump-probe signatures of vermilion (red HgS), black HgS, and metallic Hg. Pump-probe signatures of vermilion (red HgS), black HgS, and metallic.

Microrobots with different cell-carrying capacities under different grid lengths (lg) and burr lengths (lb). Microrobots with different cell-carrying capacities.

Fig. 4 Reentrant and doubly reentrant transition state analysis.

Fig. 4 Rotation of nuclei in oocytes in the primordial follicles.

Fig. 1 Map of water stress and shale plays.

Fig. 6 Different models of assembly of Ch-CNC droplets laden with Fe3O4NPs under magnetic field. Different models of assembly of Ch-CNC droplets laden.

Fig. 2 Reference-fixing experiment, results.

The wild-type BRCA1-BARD1 EM structure resembles a clamp-like motif

Fig. 3 Swarm material properties.

Breaking CAPTCHAs using a generative vision model.

Fig. 3 Scan rate effects on the layer edge current.

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 1 Cryo-EM structure of yeast Elp123 showing its active site.

Fig. 2 Full-frame images recording the violation of a Bell inequality in four images. Full-frame images recording the violation of a Bell inequality in.

Fig. 2 EUV TG signal. EUV TG signal. Black lines in (A), (B), and (C) are the EUV TG signals from Si3N4 membranes at LTG = 110, 85, and 28 nm, respectively,

Fig. 4 EUV TG signal from Si.

Fig. 6 Longevity and mechanical perturbation of a liquid membrane.

Fig. 4 Control analyses ensured that the relation between rotational acceleration and changes in FA does not depend on thresholds. Control analyses ensured.

Fig. 1 Visualization of spatial distribution of head hits in 38 collegiate football players (RSHI cohort) in a season of play. Visualization of spatial.

Fig. 1 Data collection at a 40° tilt angle enabled reconstruction of a cryo-EM map of the NRTN-GFRα2-RET complex at a 5.7-Å resolution. Data collection.

Microscopic structural order analysis of SS-annealed cylinder patterns

Fig. 3 ET dynamics on the control and treatment watersheds during the pretreatment and treatment periods. ET dynamics on the control and treatment watersheds.

Fig. 1 X-ray scattering and EBSD analyses of the bulk Fe25Co25Ni25Al10Ti15 HEA. X-ray scattering and EBSD analyses of the bulk Fe25Co25Ni25Al10Ti15 HEA.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 3 Collective modes of charge order in LBCO propagate diffusively.

Fig. 4 Demonstration of dynamic scale invariance at long times.

Fig. 3 Characterization of the current-induced effective fields.

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 1 HST/STIS spectra showing a distinct 450nm spectral feature, consistent with an NaCl F-center absorption, and a clear lack of a 720nm NaCl M-center.

Fig. 4 BS-SEM images, ternary diagrams, and phase maps for the text and reverse sides of the TS. BS-SEM images, ternary diagrams, and phase maps for the.

Fig. 3 Raman spectra for the composite materials of the TS.

Fig. 2 NP characterization.

Fig. 1 Location of the Jirzankal Cemetery.

Jetting phase analysis.

Fig. 1 Structural and electrical properties of Bi2Se3/BaFe12O19.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 2 Large-scale μXRF and EDS characterization of the text-containing side of the TS. Large-scale μXRF and EDS characterization of the text-containing.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 1 Example of diversified propagation patterns of the MJO.

Fig. 6 MD simulations of assembled binary supraballs.

Fig. 4 Effect of ionic content of LC medium.

Fig. 2 Latitudinal changes in the sea-ice drivers.

Fig. 5 Density plots showing the relationship between growth responses to extreme events and site-level mean precipitation from all sites (N = 1314). Density.

Fig. 3 Supraballs and films assembled from binary 219/217nm SPs/SMPs.

Fig. 2 Supraballs and films from binary SPs.

Fig. 1 Schematic structure of a fluorescently labeled eGLP1-conjugated MALAT1 ASO and internalization of fluorescent eGLP1 and eGLP1-MALAT1-ASO. Schematic.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

The combined signal spectra of PSD for protons and helium nuclei

Fig. 1 Design principle and SEM characterization of super-origami DNA nanostructures with n-tuples. Design principle and SEM characterization of super-origami.

Distribution of applications from AA/B scientists across topics

Fig. 2 Daily TNC pickups and drop-offs for an average Wednesday in fall 2016 (1). Daily TNC pickups and drop-offs for an average Wednesday in fall 2016.

Fig. 3 Switchable adhesion influenced by structural design and object conductivity. Switchable adhesion influenced by structural design and object conductivity.

Fig. 4 Evolution of rate constants over varying interaction strengths.

Fig. 8 Immune correlates of protection.

TRPC5 ion conduction pathway compared with TRPC4 and other TRPCs

Evaluating the performance of the robotic system through comparison with human trackers. Evaluating the performance of the robotic system through comparison.

Presentation transcript:

Fig. 4 Chromatin is a disordered chain that has diameters between 5 and 24 nm and is packed together at different concentration densities in interphase nuclei. Chromatin is a disordered chain that has diameters between 5 and 24 nm and is packed together at different concentration densities in interphase nuclei. (A) ChromEMT enables the ultrastructure of individual chromatin chains, megabase domains, and mitotic chromosomes to be resolved and visualized as a continuum in serial slices through large 3D volumes. (B) Reconstructed eight-tilt EMT data set (SAEC #1) of ChromEM-stained SAECs comprising 121 TSs (each 1.28 nm thick). Scale bar, 100 nm. To visualize chromatin and 3D organization as a continuum through the entire EMT data set, we compiled serial slices into a movie (Movie 2). (C) Manual measurements of chromatin diameters in a single TS. Scale bar, 50 nm. (D) The central EMT volume [red box in (B), 963 nm by 963 nm by 120 nm] was divided into an 8-by-8 grid comprising 64 subvolumes of 120-nm cubes. Chromatin volume concentrations (CVCs) are shown in the heat map. Scale bar, 100 nm. (E to G) The surface-thickness function was used to determine chromatin diameters in subvolumes with high (45%), medium (35%), and low (25%) CVCs. Irrespective of CVC, there are two major bin peak distributions for chromatin diameter: 5 to 12 nm and 12 to 24 nm. Scale bar, 20 nm. (H to J) Continuous erosion analysis to determine average chromatin diameter. The residual chromatin volume (Ve/Vtotal) is plotted against the spherical mean filter radius. The average radius of chromatin in each subvolume is the x-axis intercept of a linear fit of the first five erosion factor sizes. Horng D. Ou et al. Science 2017;357:eaag0025 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works