Gene promoter methylation analysis in ductal lavage fluid from cancer-free women at high risk for breast cancer and in women undergoing mastectomy for.

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Presentation transcript:

Gene promoter methylation analysis in ductal lavage fluid from cancer-free women at high risk for breast cancer and in women undergoing mastectomy for breast cancer. Gene promoter methylation analysis in ductal lavage fluid from cancer-free women at high risk for breast cancer and in women undergoing mastectomy for breast cancer. Based on the 90th percentile rank of 60 high-risk control women (A, scale 0-20 cumulative methylation index units), an upper threshold of normal was defined (horizontal line in A and B; for 9 genes = 2.00 cumulative methylation units). For ductal lavage samples from women undergoing mastectomy, cumulative methylation index values are shown in B (scale 0-20 cumulative methylation index units). Inset, full scale (0-300 cumulative methylation index units). Top, duct histology: ductal or lobular carcinoma in situ (CIS), invasive carcinoma (INV), hyperplasia of usual type (HUT), atypical hyperplasia (AH), normal (N), and unknown (UNK). Bottom, ductal lavage cytology: benign (Ben); mild atypia (Mild); marked atypia (Mark); malignant (Malig); insufficient cellular material for diagnosis (ICMD). Mary Jo Fackler et al. Clin Cancer Res 2006;12:3306-3310 ©2006 by American Association for Cancer Research