Relationship between urine flow rate and osmolality for a fixed osmolar excretion of 735 mosm/d (corresponding to an osmolar clearance of 1.7 ml/min when.

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Presentation transcript:

Relationship between urine flow rate and osmolality for a fixed osmolar excretion of 735 mosm/d (corresponding to an osmolar clearance of 1.7 ml/min when plasma osmolality [Posm] = 300 mosm/kg H2O). Relationship between urine flow rate and osmolality for a fixed osmolar excretion of 735 mosm/d (corresponding to an osmolar clearance of 1.7 ml/min when plasma osmolality [Posm] = 300 mosm/kg H2O). Ordinate: Urine flow rate or solute-free water clearance (CH20). When Uosm = Posm, urine flow rate = osmolar clearance and solute-free water clearance = 0. The rates of water reabsorption required to successively double Uosm from 75 to 1200 mosm/kg H2O are shown by vertical arrows and quantified in the insert. The amount of water “saved” by the effects of AVP is relatively large when the starting Uosm is less than that of plasma (hypo-osmotic); however, the amount “saved” declines sharply when urine is concentrated above that of plasma (hyperosmotic). (Adapted from Bankir L. Cardiovasc Res 51:372–390, 2001.)‏ Vicente E. Torres et al. CJASN 2009;4:1140-1150 ©2009 by American Society of Nephrology