Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi.

Slides:

Advertisements

Similar presentations

Multidose Cold Oxygenated Blood Is Superior to a Single Dose of Bretschneider HTK- Cardioplegia in the Pig Tord Fannelop, MD, Geir Olav Dahle, MD, Pirjo-Riitta.

Advertisements

Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat Ryuzo Bessho, MD, PhD, David J. Chambers,

Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery Manuel Castellá, MD, Gerald D.

B. Zane Atkins, MD, Scott C. Silvestry, MD, Ravi N. Samy, MD, Ashish S

Coronary Artery Bypass for Heart Failure in Ischemic Cardiomyopathy: 17-Year Follow- Up Marco Pocar, MD, PhD, Andrea Moneta, MD, Adalberto Grossi, MD,

Celsior versus custodiol: early postischemic recovery after cardioplegia and ischemia at 5°C Juergen Ackemann, MD, Wolfgang Gross, PhD, Martin Mory,

Early reperfusion with warm, polarizing adenosine–lidocaine cardioplegia improves functional recovery after 6 hours of cold static storage Donna M. Rudd,

Failure of Preconditioning to Improve Postcardioplegia Stunning of Minimally Infarcted Hearts Bouchaib Faris, Jacqueline Peynet, Michel Wassef, Alain.

Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial.

Intracoronary Shunt Prevents Ischemia in Off-Pump Coronary Artery Bypass Surgery Jacob Bergsland, MD, Per Snorre Lingaas, MD, Helge Skulstad, MD, PhD,

Gefeng Li, John A. Sullivan, John M. You, Richard I. Hall

Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach Michael T. Kronon,

Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn.

Assessment of Continuous Cold Blood Cardioplegia in Coronary Artery Bypass Grafting Yves A.G Louagie, Emmanuel Gonzalez, Jacques Jamart, Brigitte Malhomme,

Cytokines Link Toll-Like Receptor 4 Signaling to Cardiac Dysfunction After Global Myocardial Ischemia John Cha, MD, Zhiping Wang, MD, Lihua Ao, BS, Ning.

Calcium-Channel Blockers Preserve Coronary Endothelial Reactivity After Ischemia- Reperfusion François Dagenais, MD, Raymond Cartier, MD, Charleen Hollmann,

The role of cardioplegia induction temperature and amino acid enrichment in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD,

Walter J. Scott, M.D., Bruce L. Gewertz, M.D.

Superiority of magnesium cardioplegia in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson,

Sonia C Nicholson, MA, Marian Squier, MBBS, David J

Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: Phosphorus 31—nuclear magnetic resonance measurements.

Comparative Effects of Continuous Warm Blood and Intermittent Cold Blood Cardioplegia on Coronary Reactivity Motohisa Tofukuji, MD, PhD, Alon Stamler,

Osamu Katayama, MD, Simon J

Public policy and the practicing physician

Long-term treatment with nipradilol, a nitric oxide–releasing β-adrenergic blocker, enhances postischemic recovery and limits infarct size Yoshihiro.

Initial Clinical Experience With the Symphony Heart Assist System

Opioid preconditioning: myocardial function and energy metabolism

High-Dose Isosorbide Dinitrate for Myocardial Revascularization With Composite Arterial Grafts Jacob Gurevitch, MD, Hylton I Miller, MB, Itzhak Shapira,

Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction Shigetoshi.

Intraoperative myocardial protection: current trends and future perspectives Gideon Cohen, MD, Michael A Borger, MD, Richard D Weisel, MD, Vivek Rao,

Effects of cardioplegia on vascular function and the “no-reflow" phenomenon after ischemia and reperfusion: Studies in the isolated blood-perfused rat.

Normokalemic adenosine–lidocaine cardioplegia: Importance of maintaining a polarized myocardium for optimal arrest and reanimation Kathryn L. Sloots,

Intermittent aortic crossclamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): Is it preconditioning?

Technical aspects of double-skeletonized internal mammary artery grafting Jacob Gurevitch, MD, Amir Kramer, MD, Chaim Locker, MD, Itzhak Shapira, MD,

The Contribution of Na/H Exchange to Ischemia-Reperfusion Injury After Hypothermic Cardioplegic Arrest Takashi Yamauchi, MD, Hajime Ichikawa, MD, Yoshiki.

Courtney N. Zeller, Yue Wang, PhD, Troy A

Coronary Microvascular Reactivity After Ischemic Cold Storage and Reperfusion Charles O Murphy, MD, Pan- Chih, MD, John Parker Gott, MD, Robert A Guyton,

Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways Jun Feng, MD, PhD, Eliot R Rosenkranz, MD

Myocardial protection in normal and hypoxically stressed neonatal hearts: The superiority of hypocalcemic versus normocalcemic blood cardioplegia Kirk.

Mehrdad M. R. Amirhamzeh, MD, David A

Protecting the aged heart during cardiac surgery: Use of del Nido cardioplegia provides superior functional recovery in isolated hearts Arun Govindapillai,

Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia Stacy B. O’Blenes, MD, Camille Hancock Friesen, MD,

Munir Boodhwani, MD, William E

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Editorial Board, January 2010

Michael Kronon, MD. , Kirk S. Bolling, MD, Bradley S

Gregory A Thomas, MD, Larry W Stephenson, MD

Insulin cardioplegia for elective coronary bypass surgery

Improvement in functional recovery of the isolated guinea pig heart after hyperkalemic reperfusion with adenosine Helmut Habazettl, MD, Barbara W. Palmisano,

Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart Zhi-Li Cao, MD, Yukio Okazaki, MD, Kozo Naito, MD, Tetsuya Ueno,

Brian M. Cardis, MD, Derek A. Fyfe, MD, PhD, William T. Mahle, MD

Jun Feng, MD, PhD, Hongling Li, MD, MSc, Eliot R Rosenkranz, MD

Intermittent Antegrade Tepid Versus Cold Blood Cardioplegia in Elective Myocardial Revascularization Andrew C Fiore, MD, Marc T Swartz, BA, Robert Nevett,

Vascular Endothelial Growth Factor Attenuates Myocardial Ischemia-Reperfusion Injury Zhengyu Luo, Maurizio Diaco, Toyoaki Murohara, Napoleone Ferrara,

Reactive hyperemia during early reperfusion as a determinant of improved functional recovery in ischemic preconditioned rat hearts Annie Rochetaing,

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Heat shock improves recovery and provides protection against global ischemia after hypothermic storage Ashok Gowda, MS, Chunjie Yang, MD, Gregory K Asimakis,

Postischemic Function and Protein Kinase C Signal Transduction

Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide James D. McCully, PhD, Anthony J.

Effects of an Angiotensin II Antagonist on Ischemic and Nonischemic Isolated Rat Hearts Yosef Paz, Jacob Gurevitch, Inna Frolkis, Menachem Matsa, Amir.

2,3-Butanedione monoxime cardioplegia: advantages over hyperkalemia in blood- perfused isolated hearts A.Mark Jayawant, MD, Edward R. Stephenson, MD,

Intermittent Warm Blood Cardioplegia Preserves Myocardial β-Adrenergic Receptor Function Massimo Chello, Pasquale Mastroroberto, Vincenzo De Amicis,

Arrest Duration Influences Postcardioplegia Electrophysiologic Recovery and Reperfusion Arrhythmias C.Patrick Murrah, Edward R Ferguson, Russell D Spruell,

Thomas K. Waddell, MD PhD, Reginald M. Gorczynski, PhD, Kleber N

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Changes in coronary vessel resistance during postischemic reperfusion and effectiveness of nitroglycerin Gerhard A. Kalweit, MDa, Jochen D. Schipke,

David J Chambers, PhD, David J Hearse, DSc

Protamine induces vasorelaxation of human internal thoracic artery by endothelial NO- synthase pathway Dmitry Pevni, MD, Jacob Gurevich, MD, Inna Frolkis,

Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation Geoffrey P. Dobson, PhD, Michael W.

David H. Harpole, MD, Stanley A. Gall, MD, Walter G. Wolfe, MD, J

Presentation transcript:

Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi Paz, Rephael Mohr, Vladimir Yakirevich The Annals of Thoracic Surgery Volume 63, Issue 3, Pages 627-633 (March 1997) DOI: 10.1016/S0003-4975(96)00932-0 Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 1 Hemodynamic performance: peak systolic pressure. Results are shown as the percentage of baseline measurements after 15 minutes of stabilization. Before ischemia, all four groups demonstrated similar peak-systolic pressures. After ischemia, however, the control group had a significant deterioration in myocardial hemodynamics, whereas hearts given captopril either immediately before ischemia in the cardioplegic solution (Cardioplegia) or immediately after ischemia (Reperfusion) exhibited improved recovery. When captopril was given both in cardioplegia and during reperfusion (Card & Rep), peak systolic pressure was significantly better than in all three other groups (p < 0.001), and left ventricular hemodynamic deterioration was minimal. The Annals of Thoracic Surgery 1997 63, 627-633DOI: (10.1016/S0003-4975(96)00932-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 2 Hemodynamic performance: first derivative of rise in left ventricular pressure. Details and abbreviations are the same as in Fig. 1. The Annals of Thoracic Surgery 1997 63, 627-633DOI: (10.1016/S0003-4975(96)00932-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 3 Hemodynamic performance: pressure–time integral. Details and abbreviations are the same as in Fig. 1. The Annals of Thoracic Surgery 1997 63, 627-633DOI: (10.1016/S0003-4975(96)00932-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 4 Coronary flow before and after ischemia. Results are shown as the percentage of baseline measurements after 15 minutes of stabilization. Before ischemia, all four groups performed similarly. After ischemia, hearts treated with captopril had a significantly better recovery and viability compared with the control group in terms of coronary flow (p < 0.001). Hearts treated with captopril both before and after ischemia (Card & Rep) had the best results, and when this group was compared with the control group, analysis of variance for drug effect was most prominent (p < 0.001). (Cardioplegia = hearts given captopril in cardioplegic solution; Reperfusion = hearts given captopril during reperfusion.) The Annals of Thoracic Surgery 1997 63, 627-633DOI: (10.1016/S0003-4975(96)00932-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig. 5 Oxygen consumption before and after ischemia. Details and abbreviations are the same as in Fig. 4. The Annals of Thoracic Surgery 1997 63, 627-633DOI: (10.1016/S0003-4975(96)00932-0) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions