Figure 1 Excitability of primary motor cortex

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Presentation transcript:

Figure 1 Excitability of primary motor cortex Figure 1 Excitability of primary motor cortex.Top: Input-output curve of MEPs at baseline in patients with Parkinson’s ... Figure 1 Excitability of primary motor cortex.Top: Input-output curve of MEPs at baseline in patients with Parkinson’s disease (PD) OFF and ON medication and in healthy controls (HC). The y-axis shows the MEP amplitudes (mV); the x-axis shows the six stimulation intensities [80%, 100%, 120%, 140%, 160% and 180% of resting motor threshold (RMT)]. Bottom: SICI and ICF at baseline in patients with Parkinson’s disease OFF medication and ON medication and in healthy controls. The y-axis shows the ratio between conditioned and unconditioned MEP amplitudes; the x-axis shows the four interstimulus intervals (2 ms and 4 ms for SICI, and 10 ms and 15 ms for ICF). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) Brain, Volume 141, Issue 8, 12 June 2018, Pages 2432–2444, https://doi.org/10.1093/brain/awy155 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2 Plasticity of primary motor cortex Figure 2 Plasticity of primary motor cortex. Course of MEPs after the PAS protocol in the abductor pollicis brevis ... Figure 2 Plasticity of primary motor cortex. Course of MEPs after the PAS protocol in the abductor pollicis brevis (APB, top) and in the first dorsal interosseous (FDI, bottom) in patients with Parkinson’s disease (PD) OFF and ON medication and in healthy controls (HC). The y-axis shows MEP amplitudes normalized to baseline (B). The x-axis shows measurements at the four time points: before PAS (B) and 5 min (T1), 15 min (T2) and 30 min (T3) after PAS. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) Brain, Volume 141, Issue 8, 12 June 2018, Pages 2432–2444, https://doi.org/10.1093/brain/awy155 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3 Schematic plot showing how the original input variables are loaded onto canonical factors I and II. The x- ... Figure 3 Schematic plot showing how the original input variables are loaded onto canonical factors I and II. The x- and y-axes indicate the loadings for canonical factors (F) I and II, respectively. For example, PAS has a strong loading on FI but very little on FII. The input-output (I/O) MEP slope and velocity intercept have a strong loading on FII and these two variables are anti-correlated. Kinematic variables (dashed line) are shown in italics. The parameters with the loadings higher than ±0.50 are in bold. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) Brain, Volume 141, Issue 8, 12 June 2018, Pages 2432–2444, https://doi.org/10.1093/brain/awy155 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 4 Schematic representation of the two major findings of the study.Top: The relationship between movement ... Figure 4 Schematic representation of the two major findings of the study.Top: The relationship between movement velocity intercept (corresponding to the values at the beginning of the motor sequence) and the input-output (I/O) MEP curve; note that the representative patient with Parkinson’s disease (PD) with severe movement slowness has a steeper input-output curve. Bottom: The relationship between amplitude decrement, i.e. the sequence effect and the MEP amplitude change after PAS. Note that the representative Parkinson’s disease patient with more severe sequence effect has no MEP amplitude increase after PAS. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) (2018). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please email: journals.permissions@oup.comThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) Brain, Volume 141, Issue 8, 12 June 2018, Pages 2432–2444, https://doi.org/10.1093/brain/awy155 The content of this slide may be subject to copyright: please see the slide notes for details.