Understanding the Expanding Armamentarium for GIST

Overview of GIST

Workup of Suspected GIST

Initial Treatment of Metastatic GIST

First-Line GIST Treatment: Imatinib

Second-Line GIST Treatment: Sunitinib

Third-Line GIST Treatment: Regorafenib

Investigational Approaches: Crenolanib

CrenoGIST: Phase 3 Trial of Crenolanib in D842V-Mutated GIST

Investigational Approaches: Avapritinib

VOYAGER: Phase 3 Trial of Avapritinib in Third- and Fourth-Line GIST

Investigational Approaches: Ripretinib

Phase 3 Trials of Ripretinib in GIST

Other Novel Strategies

Key Takeaways

Abbreviations

Abbreviations (cont)