Example inverse FF-OCT images (left column) and corresponding histology images (right column) of ovarian metastases. Example inverse FF-OCT images (left.

Slides:

Advertisements

Similar presentations

Ovary and Primary Peritoneal Carcinoma Anatomic sites of the ovary and peritoneum. Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas,

Advertisements

Regional lymph nodes and distal extracranial metastases are not a reliable surrogate for actionable mutation in brain metastases. Regional lymph nodes.

Development of preclinical models for the guidance of precision medicine. Development of preclinical models for the guidance of precision medicine. A,

Immunohistochemical staining for RXR subtypes within benign and endometrioid endometrial carcinoma. Immunohistochemical staining for RXR subtypes within.

PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.

Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating lymphocytes. Geographic distribution in situ of MSI and MSS colorectal cancer–infiltrating.

High-throughput analysis of informative CpG sites for the four studied tumor suppressor genes (A-D). High-throughput analysis of informative CpG sites.

Expression of CD36 and psap in a TMA of human ovarian cancer patients

Capture of CK+ and CK− complex aneuploid CTCs in breast, ovarian, or colorectal cancer. Capture of CK+ and CK− complex aneuploid CTCs in breast, ovarian,

Figure 3 Optical coherence tomography images of specialized intestinal

Bioluminescence imaging facilitates detection of tumor growth and metastasis in mouse orthotopic xenograft model. Bioluminescence imaging facilitates detection.

mpJX-594 effects on tumor burden and leukocyte influx.

Fig. 2. LUM015 fluorescently labels tumor cells in mouse models of STS and breast cancer. LUM015 fluorescently labels tumor cells in mouse models of STS.

Methylation status of IGFBPL1 in human breast cancer.

Peripheral CAF model. Peripheral CAF model. A, bright field (top) and fluorescence (bottom) micrographs of aggregates that contain RFP-tagged 344SQ cells.

Dietary plant extracts inhibit NF-κB activation in vitro.

IL32 is highly expressed in mycosis fungoides lesional skin.

FAK overexpression in invasive human breast cancer and DCIS

SDF-1/CXCR4 axis is involved in CD133+ tumor cell metastasis toward a lymphatic metastasis niche. SDF-1/CXCR4 axis is involved in CD133+ tumor cell metastasis.

LINC00092 binds with PFKFB2 to promote ovarian cancer metastasis.

CXCL14-positive CAFs induce overexpression of LINC00092 in ovarian cancer. CXCL14-positive CAFs induce overexpression of LINC00092 in ovarian cancer. A,

DNA recombination at sites of replication damage in BLM-deficient cells. DNA recombination at sites of replication damage in BLM-deficient cells. A. Nucleotide.

Antigen-specific CD8+ T cells express higher levels of PD-1 in animals that received the optimized SSX2 vaccine. Antigen-specific CD8+ T cells express.

Matriptase-2 inhibited breast tumor development in vivo.

Effect of nicotinamide and carbogen on 5-FU uptake (measured as SUV3

MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting Sox2. MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting.

Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs.

EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo. EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo.

Immunohistochemistry for phosphorylated (S235) S6 ribosomal protein and quantitation of Ki67 labeling indices in vehicle- and WAY –treated Eker (Tsc2+/−)

MPGES is expressed in epithelial cells in benign and malignant tumors of the colon. mPGES is expressed in epithelial cells in benign and malignant tumors.

Antitumor activity of AMG 102 in combination with bevacizumab or motesanib. Antitumor activity of AMG 102 in combination with bevacizumab or motesanib.

ALDH1A3 expression levels are inversely correlated with the survival of patients with resectable mass-forming and advanced cholangiocarcinoma, respectively.

MRNA expression IL-1α, IL-1β, IL-1Ra, IL-1RtI, ER α, ER β, and PR was analyzed by RT-PCR as described in “Materials and Methods.” Representative gel electrographies.

Molecular signatures are independent of tumor stage and grade.

HCCs with overexpression of biliary/progenitor marker genes.

Expression of XCR1 in normal ovarian surface epithelium and the IOSE and borderline EOC cell lines. Expression of XCR1 in normal ovarian surface epithelium.

Immunohistochemical staining of primary and metastatic prostatic carcinomas with anticyclin D1 and anti-Ki67 monoclonal antibodies. Immunohistochemical.

Serial imaging before and after immunotherapy among patients with MDM2/4 amplifications (N = 6). Serial imaging before and after immunotherapy among patients.

Rif/mDia2 signaling in primary tumor formation and spontaneous metastasis. Rif/mDia2 signaling in primary tumor formation and spontaneous metastasis. A,

Duration of treatment and intervals of radiographic and ctDNA response

ESKM is superior to ESK1 in vivo, and is effective against multiple tumor models. ESKM is superior to ESK1 in vivo, and is effective against multiple tumor.

Influenza vaccine enhances NK cell function through IFN-α.

Gamma camera images at 72 h of patient with T4N2M1 ductal breast cancer (patient 6). Gamma camera images at 72 h of patient with T4N2M1 ductal breast cancer.

Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.

Noninvasive detection of acquired MET amplification as a mechanism of afatinib/trastuzumab resistance using cfDNA. Noninvasive detection of acquired MET.

Effect of CDV on human SF7796 xenografts in vivo.

Location of the ER mutations and frequencies per cohort.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.

Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.

Specific reaction with MIB1, M30, and CD31 monoclonal antibodies in primary human cervical carcinoma before (A, C, and E) and after (B, D, and F) Tam treatment.

Effect of silencing β-catenin on the invasion and metastasis of MHCC97 and Hep3B cells under normoxic and hypoxic conditions. Effect of silencing β-catenin.

SPARC is required for spontaneous metastasis

MGA271 exhibits potent in vivo antitumor activity toward tumor cell carcinoma xenografts. MGA271 exhibits potent in vivo antitumor activity toward tumor.

Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

Proliferation of TA3-Ha and TA3-St cells in vitro and in vivo.

Representative biodistribution pattern of 111In-CMD-193.

Effects of ZOL treatment on pulmonary metastases.

In the presence of human monocytes, estradiol increased breast cancer cell dissemination to the periphery via CCL2 and CCL5. In the presence of human monocytes,

Relative frequencies of FGFR aberrations in non–small cell lung carcinoma. Relative frequencies of FGFR aberrations in non–small cell lung carcinoma. A,

A, heatmap of copy number alterations determined by array CGH for a panel of 79 frozen NSCLC samples. A, heatmap of copy number alterations determined.

Leukocyte populations in normal and neoplastic breast tissues.

Tumor spheroid induces mesothelial cell migration.

Frequency and number of KLL-specific clonotypes in tumors from patients with KLL-specific T cells in PBMCs or cultured TILs. A wedge (the length of which.

Fig. 3. Paclitaxel promotes TMEM-dependent vascular permeability, cancer cell dissemination, and metastasis in breast cancer. Paclitaxel promotes TMEM-dependent.

Gene expression heatmap of non–T-cell-inflamed, intermediate, and T-cell–inflamed testicular germ cell tumors from TCGA. Genes are on the row, and samples.

Fig. 3 Minimal treatment of ETL decreases metastatic burden and prolongs survival in the 4T1 breast carcinoma model after tumor resection. Minimal treatment.

SCLC initiated from pulmonary neuroendocrine cells metastasizes without upregulating NFIB. A and B, Mouse models of SCLC. Rb1flox/flox;Trp53flox/flox;p130flox/flox;R26mTmG.

Tumor progression is required prior to metastasis of SCLC in both CMV TKO and CGRP TKO mice. Tumor progression is required prior to metastasis of SCLC.

The inverse correlation between PARP1 and PD-L1, PAR, and p-STAT3 expression in surgical specimens of ovarian cancer. The inverse correlation between PARP1.

Presentation transcript:

Example inverse FF-OCT images (left column) and corresponding histology images (right column) of ovarian metastases. Example inverse FF-OCT images (left column) and corresponding histology images (right column) of ovarian metastases. An ovary containing a solitary metastasis originating from a primary invasive breast carcinoma is shown in A and B (indicated by arrows). An ovary in which disseminated breast tumor cells are dispersed throughout the ovary is shown in C and D. Micrometastases originating from a primary endometrial carcinoma are shown in E and F (indicated by arrows); scale bars, 500 (A–D) and 200 μm (E–F). Inge T.A. Peters et al. Clin Cancer Res 2016;22:5506-5513 ©2016 by American Association for Cancer Research