Possible mechanisms of famillial idiopathic interstitial pneumonia leading to lung fibrosis involves apoptosis caused mainly through chronic endoplasmic.

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Presentation transcript:

Possible mechanisms of famillial idiopathic interstitial pneumonia leading to lung fibrosis involves apoptosis caused mainly through chronic endoplasmic reticulum (ER) stress. Possible mechanisms of famillial idiopathic interstitial pneumonia leading to lung fibrosis involves apoptosis caused mainly through chronic endoplasmic reticulum (ER) stress. Telomere mutations may primarily cause DNA damage once telomeres have been substantially shortened. SP-A/C: surfactant protein A/C; SFTPA/C: surfactant protein A/C gene; TR: telomerase RNA-component; TERT: telomerase reverse transcriptase. Andreas Günther et al. Eur Respir Rev 2012;21:152-160 ©2012 by European Respiratory Society