A, Stacked Venn plots of the significantly associated (FDR < 25%) KEGG pathways for 3 imaging subtypes with GSEA. B, Pathway activity scores for 3 imaging.

Slides:

Advertisements

Similar presentations

P53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer Crystal Tonnessen-Murray,

Advertisements

IL32 prompts cell activation and cancer-related pathways.

Deletion of Lats1 is phenotypically distinct from Lats2 deletion in PyMT tumors. Deletion of Lats1 is phenotypically distinct from Lats2 deletion in PyMT.

The BRD4 bromodomain is critical for expression of SASP genes.

Bar plot representation of the transcriptomic changes in Δsaci_ptp and Δsaci_pp2a. Bar plot representation of the transcriptomic changes in Δsaci_ptp and.

AZA treatment induces a distinct gene-expression pattern in stromal cells. AZA treatment induces a distinct gene-expression pattern in stromal cells. (A-C)

Number of hospitalizations for aspiration pneumonia (upper panel) and CAP (lower panel) per month across the 47 study hospitals. Number of hospitalizations.

Megakaryocyte total surface area increases with protrusion extension.

Ingenuity pathway analysis of the genes enriched in both 96-h-induced MMs and human ccRCC. Ingenuity pathway analysis of the genes enriched in both 96-h-induced.

Reanalysis of an existing experiment using ADAGE

Stage-specific expression modules of preimplantation development.

CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional profile. CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional.

Extended analysis of differential expression datasets.

Distinct molecular and clinical correlates of H3F3A mutation subgroups

Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.

Frequent alterations identified and potential actionability.

A, Overall survival of patients treated with CAR T cells (black line; n = 15). A, Overall survival of patients treated with CAR T cells (black line; n.

Immune signatures of patients with short-, medium-, and long-term survival. Immune signatures of patients with short-, medium-, and long-term survival.

Binding and internalization of bispecific immunotoxins.

Differential methylation between AA and EA cases among breast cancer subtypes. Differential methylation between AA and EA cases among breast cancer subtypes.

Development of 28 public molecular laboratories in France for molecular testing. Development of 28 public molecular laboratories in France for molecular.

Ki-67 expression is determined by the cell-cycle stage.

MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting Sox2. MiR-200c suppresses tumor growth and metastasis of CRC in vivo by targeting.

MiR-200c is a PI3K–AKT signaling pathway regulator in CRC

Identification of molecular subtypes of leiomyosarcoma (LMS) in the TCGA data. Identification of molecular subtypes of leiomyosarcoma (LMS) in the TCGA.

Peptide dose-response curves were done to estimate the avidity of these HTL for peptide TARP1-14 (A) and TARP14-27 (B-E) using autologous PBMCs and dendritic.

Immunohistochemistry for phosphorylated (S235) S6 ribosomal protein and quantitation of Ki67 labeling indices in vehicle- and WAY –treated Eker (Tsc2+/−)

EN1-associated chromatin complexes in breast cancer cells.

EN1 expression in breast cancer and clinical outcome.

ALDH1A3 expression levels are inversely correlated with the survival of patients with resectable mass-forming and advanced cholangiocarcinoma, respectively.

Specific up-regulation and down-regulation of immunomodulatory genes in human breast and colorectal cancers. Specific up-regulation and down-regulation.

FILM immunohistochemical protein signature is significantly associated with poor survival. FILM immunohistochemical protein signature is significantly.

Relative abundance of the predicted KEGG orthologous groups (KOs) in the fecal (A) and salivary (B) samples from the clindamycin group plotted against.

Molecular signatures are independent of tumor stage and grade.

Transcripts enriched and depleted in NB TICs compared with SKPs and other tumor tissues. Transcripts enriched and depleted in NB TICs compared with SKPs.

Alkaline Comet assay showing DNA break formation after 6-TG treatment, implying more SSBs generated in MMR+ cells. Alkaline Comet assay showing DNA break.

Tipifarnib combined with bortezomib induces cell death in diverse multiple myeloma and AML cell lines. Tipifarnib combined with bortezomib induces cell.

Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. A, bar.

Tipifarnib and bortezomib are synergistic in cytotoxicity assays

Duration of treatment and intervals of radiographic and ctDNA response

CREBBP loss-of-function results in gene expression repression signature. CREBBP loss-of-function results in gene expression repression signature. A–D,

Example inverse FF-OCT images (left column) and corresponding histology images (right column) of ovarian metastases. Example inverse FF-OCT images (left.

RUNX3 depletion induces cellular senescence and inflammatory cytokine expression in cells undergoing TGFβ-mediated EMT. A, Cells were transfected with.

Mean cell number in small intestinal crypt (a), small intestinal villus (b), and midcolonic crypt (c) of BALB/c (♦) and DBA/2 (▪) mice after two injections.

Tivantinib behaves as an antimitotic agent.

High-throughput drug screen (HTDS) reveals ARS1620 and PI3K pathway inhibitors synergies and a heterogeneous pattern of RTK synergies. High-throughput.

PK profile of OTL78. PK profile of OTL78. A, Representative time-dependent whole-body fluorescence images over white light images of a mouse bearing 22Rv1.

Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

Association of overall survival and PAP-specific (A, B) and PA2024-specific (C, D) CTL activity at week 26 using categorical (tertile) analysis and continuous.

Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R mg/kg (n.

Identification of general and tissue-specific essential genes.

A, Selected 4 quantitative imaging features significantly associated with 3 imaging subtypes, including tumor volume, tumor sphericity, tumor homogeneity.

Fig. 2 Tissue-specific transcriptomic alterations in response to acute sleep loss in healthy humans. Tissue-specific transcriptomic alterations in response.

Global mutational landscape of the 170 lung adenocarcinoma patients (discovery cohort). Global mutational landscape of the 170 lung adenocarcinoma patients.

Putative molecular pathways showing how GSK3β regulates the fate of tumor cells (survival, proliferation, or apoptosis) and influences their sensitivity.

Fig. 6 SVR analysis relating the spatial fingerprint of head impacts to hemispheric asymmetries in white matter. SVR analysis relating the spatial fingerprint.

Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

Reduced expression of the tumor suppressor PTEN occurs in tumors with both squamous cell and adenocarcinoma histology. Reduced expression of the tumor.

Interaction of NHEJ and HR pathways in PCO cultures.

Biopsies of the vaccination site were obtained 48 h after the first vaccination. Biopsies of the vaccination site were obtained 48 h after the first vaccination.

Distinct subtypes of CAFs are detected in human PDAC

An isogenic cell line screen reveals genomic drivers of drug response.

Venn diagram showing the overlap of PD-L1 overexpression, MSI-NGS–high, and TML-high in all gastrointestinal tumors, with all three markers tested (N =

Identification and characterization of activated integrin pathway module by signal transduction representation (A) and unsupervised hierarchical clustering.

Mean BMI z scores in 6- to 9-year-old white girls with and without breast development, based on the PROS study data reported by Kaplowitz et al.13 The.

Transcriptome profiling of PD-L1 antibody–treated macrophages showed inflammatory phenotype, increased survival and proliferation, and decreased apoptosis.

Characteristic gene expression patterns distinguish LCH cells from other immune cells present in LCH lesions. Characteristic gene expression patterns distinguish.

Bioinformatic analyses suggest that PI3K/AKT signaling may be a key downstream pathway of tazarotene signaling. Bioinformatic analyses suggest that PI3K/AKT.

CONSORT diagram. a, 5 had a major treatment violation (3 refused and 2 received wrong treatment) but were included in the analyses; b, 4 had a major treatment.

Presentation transcript:

A, Stacked Venn plots of the significantly associated (FDR < 25%) KEGG pathways for 3 imaging subtypes with GSEA. B, Pathway activity scores for 3 imaging subtypes. A, Stacked Venn plots of the significantly associated (FDR < 25%) KEGG pathways for 3 imaging subtypes with GSEA. B, Pathway activity scores for 3 imaging subtypes. The pathways are from NCI Pathway Interaction Database Pathways, which are significantly (FDR < 25%) associated with 3 imaging subtypes with PARADIGM analysis. The bar length indicates the magnitude of activity score. From 2 independent pathway analyses, we observed consistent pathway dysregulation patterns across imaging subtypes, which might explain the differential prognoses associated with the 3 imaging subtypes. Jia Wu et al. Clin Cancer Res 2017;23:3334-3342 ©2017 by American Association for Cancer Research