MDC/CCL22 and MMP-2 factors are found in the melanoma microenvironment and correlate with pDC accumulation and early relapse. MDC/CCL22 and MMP-2 factors.

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MDC/CCL22 and MMP-2 factors are found in the melanoma microenvironment and correlate with pDC accumulation and early relapse. MDC/CCL22 and MMP-2 factors are found in the melanoma microenvironment and correlate with pDC accumulation and early relapse. A and B, the factors TARC, MDC, TSLP, and MMP-2 were quantified in tumor supernatants collected from melanoma-bearing Humice (A, n = 49) and melanoma patients (B, n = 20). C, correlation between the frequency of tumor-infiltrating pDCs and the level of MDC (left) or MMP-2 (right) found within the same patient's tumors (n = 15). D, correlation between the PFS and the level of MDC found in patients' tumors (n = 10). Caroline Aspord et al. Cancer Immunol Res 2013;1:402-415 ©2013 by American Association for Cancer Research