Extraction diagram of candidate genes identified by global expression analysis. Extraction diagram of candidate genes identified by global expression analysis.

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Extraction diagram of candidate genes identified by global expression analysis. Extraction diagram of candidate genes identified by global expression analysis. For transcriptome analysis, surgically resected specimens of 16 patients with stage III gastric cancer who underwent curative gastrectomy and adjuvant S-1 monotherapy were selected. These 16 patients were categorized into four clusters (4 patients per cluster) according to clinical courses as follows: cluster 1, no recurrences (rec.) for >5 years; cluster 2, hepatic-confined recurrences within 2 years after surgery; cluster 3, peritoneal recurrences within 2 years after surgery; and cluster 4, distant nodal recurrences within 2 years after surgery. Global expression profiling was conducted to compare the expression levels of 57,749 genes between each cluster. They were filtered to yield 67 genes associated with significant differences in expression (P < 0.05 and Q < 0.05) between clusters 1 and 2. We next filtered these 67 genes according to P ≥ 0.05 for the no-recurrence group vs. the nodal-recurrence group and P ≥ 0.05 for the no-recurrence group vs. the peritoneal-recurrence group to yield 32 genes. Among them, 32 genes that were upregulated in cluster 2 and comprised coding sequences were filtered to yield 21 genes, which we considered candidates drivers of hematogenous metastasis (Table 1). Haruyoshi Tanaka et al. Mol Cancer Res 2018;16:1420-1429 ©2018 by American Association for Cancer Research