PD-L1 is expressed in breast cancer.

Slides:

Advertisements

Similar presentations

Expression of immune checkpoint molecules on leukocytes and tumor cells at baseline and in response to selinexor. Expression of immune checkpoint molecules.

Advertisements

PD-1 and LAG-3 expression in MSI and MSS colorectal cancer specimens.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Fig. 1 Localized treatment of TNBC cancers kills tumor cells and minimizes the metastatic burden. Localized treatment of TNBC cancers kills tumor cells.

Representative multiplex immunofluorescence image of synovial sarcoma with increased PD-L1/PD-1/CD8 cell densities at the tumor-invasive margin demonstrating.

Treatment of human MCC tumors with intralesional IFNβ is associated with MHC-I upregulation. Treatment of human MCC tumors with intralesional IFNβ is associated.

Expression of Two Breast-Specific Molecules in the Lung

Tregs and APC subsets in TDLNs of patients with cervical cancer.

PD-1 expression on HCC-infiltrating B cells and its clinical significance. PD-1 expression on HCC-infiltrating B cells and its clinical significance. A–H,

Fold Change of hsa-miR-3687 (T/N)(log2)

Increase in beige/brown adipocyte characteristics in the xenografts from additional breast cancer cell lines. Increase in beige/brown adipocyte characteristics.

Quantification of MHC-I, β2m, and T-cell subsets.

SIRT1 is downregulated in human gastric cancer (GC).

Knockdown of endogenous WT-hTER by a short hairpin RNA (siRNA) directed specifically against the human WT telomerase RNA template. Knockdown of endogenous.

Pathology slide of the meningeal tissue from a left temporal craniotomy shows inflammatory cells with lymphoplasmacytic infiltration, foamy histiocytes,

Gene expression changes associated with response to combination CPI-444 and anti–PD-L1 treatment in MC38 tumors. Gene expression changes associated with.

TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor tissues. TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor.

Autophagy restrains pancreatic inflammation and expression of pTBK1, CCL5, and PD-L1 in vivo. Autophagy restrains pancreatic inflammation and expression.

Combined BRAFi and anti-CTLA4 administration leads to prolonged antitumor immunity in a patient with metastatic melanoma. Combined BRAFi and anti-CTLA4.

Increased CCL5 expression, infiltration of Treg cells, and apoptosis of CD8+ T cells in human colorectal tissues. Increased CCL5 expression, infiltration.

Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the.

IL32 is highly expressed in mycosis fungoides lesional skin.

Antitumor activity of HER2-lytic hybrid peptide in tumor xenograft model in vivo. Antitumor activity of HER2-lytic hybrid peptide in tumor xenograft model.

FAK overexpression in invasive human breast cancer and DCIS

coTCRcys-transduced T cells control tumor growth in vivo.

Validation of the screen hits.

FAK overexpression in invasive human colon cancer and colon dysplasia.

Supplementary Figure S1

Selective delivery of pIC/PPHAffibody decreases the survival of HER2-overexpressing cells. Selective delivery of pIC/PPHAffibody decreases the survival.

CNDT2.5 cells express mRNA for synaptophysin and neuron-specific enolase. CNDT2.5 cells express mRNA for synaptophysin and neuron-specific enolase. RT-PCR.

CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated with a longer survival. CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated.

Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs.

Melanoma patient monocytes have altered expression of inflammatory and surface markers. Melanoma patient monocytes have altered expression of inflammatory.

A, RT-PCR expression of matriptase-1 and matriptase-2 in a variety of 24 human cell lines. A, RT-PCR expression of matriptase-1 and matriptase-2 in a variety.

EN1 expression in breast cancer and clinical outcome.

SAF-1 expression in clinical breast cancer tissues.

Epithelial-derived cancer cells and tumor-residing APCs have higher HLA-E expression but reduced MHC-1a expression. Epithelial-derived cancer cells and.

CDN–treated MOC1 tumors demonstrate enhanced activation of innate and antigen-specific adaptive immunity. CDN–treated MOC1 tumors demonstrate enhanced.

Expression of S100A11 in bulk pancreatic tissues (pancreatic cancer, n = 22; IPMN, n = 18; nonneoplastic pancreas, n = 22). Expression of S100A11 in bulk.

Effect of hydrogen peroxide on survival and transcriptional activation of TFF1 in established cell lines from the following human tumor tissues: breast.

Combination CDN and PD-L1 mAb treatment of established MOC1 tumors produces consistent tumor rejection. Combination CDN and PD-L1 mAb treatment of established.

Intratumoral lymphoid aggregates are sites of postvaccination T-cell activation and regulation. Intratumoral lymphoid aggregates are sites of postvaccination.

Nested RT-PCR of Mammaglobin and CK19 mRNA in plasma and circulating cells of controls (C) and patients (T) with breast cancer. Nested RT-PCR of Mammaglobin.

NT157 treatment inhibits LNCaP xenograft growth and delays castration-resistant progression. NT157 treatment inhibits LNCaP xenograft growth and delays.

Reduced klotho expression in pancreatic cancer.

Expression of versican promoted breast cancer cell tumor formation and self-renewal in vivo. Expression of versican promoted breast cancer cell tumor formation.

PD-1 expression in ovarian cancer.

Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors. Met is expressed in Her2-overexpressing cell lines and Her2 (+) breast tumors.

Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.

Intraperitoneal or intratumoral injection of 6-thio-dG or 6-thioguanine. Intraperitoneal or intratumoral injection of 6-thio-dG or 6-thioguanine. A, 2.

CPI-444 enhances T-cell activation in MC38 tumors.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

Tumorigenicity of GR CAFs

Combination of R848 and anti-CD200R affects activation of tumor-infiltrating myeloid cells. Combination of R848 and anti-CD200R affects activation of tumor-infiltrating.

LDL cholesterol inhibits Vγ9Vδ2 T-cell activation and cytokine production. LDL cholesterol inhibits Vγ9Vδ2 T-cell activation and cytokine production. Preexpanded.

PARP1 suppresses the transcription of PD-L1 in cancer cells.

Expression of chemokine receptors in A-498 cell line.

Increased tumorigenic activities of TIM-3–expressing RCC cells.

This nasal inflammatory myofibroblastic tumor is composed of a storiform array of plump spindle cells with a background of chronic inflammatory infiltrate.

PTEN genotype frequently dictates PTEN expression status, but evidence of heterogeneous staining implies polyclonality within some ovarian tumors. PTEN.

Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells. Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells.

Cell counts of immune infiltrate and expression of galectin-1 and galectin-3 in the short-, medium-, and long-term survival cohorts. Cell counts of immune.

Depletion of murine Dnmt proteins after 5-Aza-CdR treatment.

EC-derived SP cells are targeted by CD30.CAR T cells.

PD-L1 expression is not associated with PTEN expression status in melanomas. PD-L1 expression is not associated with PTEN expression status in melanomas.

The inverse correlation between PARP1 and PD-L1, PAR, and p-STAT3 expression in surgical specimens of ovarian cancer. The inverse correlation between PARP1.

Coincidence and prognostic significance of PD-1+ and CD103+ cells in HGSC. Serial sections from the 490-case TMA were stained with antibodies to CD103.

Silencing E4BP4 abrogates the promoting effect of SMAD3 knockdown on IFNγ production in NK-92 cells. Silencing E4BP4 abrogates the promoting effect of.

RIL21 and checkpoint blockade restore IFNγ production in Tim-3+PD-1+ intratumoral NK cells from cancer patients. rIL21 and checkpoint blockade restore.

IHC staining of FFPE esophageal tissues in tissue microarrays (×20).

Presentation transcript:

PD-L1 is expressed in breast cancer. PD-L1 is expressed in breast cancer. A, analysis of TCGA data demonstrated higher PD-L1 mRNA expression in breast tissue specimens from patients with TNBC (n = 120) in contrast with patients with non-TNBC (n = 716). Data are mean ± SD of PD-L1 mRNA expression. Analysis was done using a t test. Log2 expression of PD-L1 is shown on the y-axis. B, PD-L1 mRNA expression (mean ± SD) in breast cancer patient tumors was measured using RT-PCR. RNA was extracted from breast cancer cells that were isolated from tumors using LCM (1–5). Cytokeratin 7 (CK7) was used as a marker of breast cancer to confirm the source of the extracted RNA. MDA-MB-231 was used as a positive control for PD-L1. C, representative TNBC patient tumor tissues showing loss of PTEN expression and high PD-L1 expression in tumor cells, and a significant CD8+ T-cell infiltrate in contrast with another TNBC patient tissue (D), which shows high PTEN expression in breast tumor cells, no PD-L1 expression in tumor cells, minimal PD-L1 expression in associated inflammatory cells, and minimal intratumoral CD8+ T-cell infiltrate. Magnification, ×100. H&E, hematoxylin and eosin. Elizabeth A. Mittendorf et al. Cancer Immunol Res 2014;2:361-370 ©2014 by American Association for Cancer Research