IGF-I partially protects Rh30 cells from apoptosis despite simultaneous inhibition of PI3K-Akt and MAP kinase pathways. IGF-I partially protects Rh30 cells.

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IGF-I partially protects Rh30 cells from apoptosis despite simultaneous inhibition of PI3K-Akt and MAP kinase pathways. IGF-I partially protects Rh30 cells from apoptosis despite simultaneous inhibition of PI3K-Akt and MAP kinase pathways. Rh30 cells were grown under serum-free conditions and treated with inhibitors of MEK1 and PI3K with or without IGF-I (10 ng/ml) for 45 h. A, DMSO 0.1% (control), IGF-I (10 ng/ml). B, PD98059 (15 μm). C, LY 294002 (20 μm). D, PD98059 (15 μm) plus LY 294002 (20 μm). Ordinate is the uptake of propidium iodide (PI); the abscissa, annexin V-FITC fluorescence (top panels). Viable cells are represented in the bottom left quadrant. The bottom panels show the corresponding distribution of annexin V-FITC staining of cell populations. Apoptosis was determined after 45 h by quantitative FACS analysis (ApoAlert). The percentage of distribution of cells in each quadrant is presented. Kuntebommanahalli N. Thimmaiah et al. Cancer Res 2003;63:364-374 ©2003 by American Association for Cancer Research