Table 2. Experimental research selected to review

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Table 2. Experimental research selected to review Author/year Intervention Main Outcome Seif et al., 2014 Received 200µg/day of CrPic via gavage for 10 weeks ↓Platelet hyperaggregability ↓Risk of cardiovascular disease ↑Improve lipid profile Normalize ADP, collagen-induced hyperaggregability and levels of TX B2 Huang et al., 2014 Offered three concentrations of CrPic (25, 50, 100 µg/kg) for 15 weeks ↓Macroangiopathy ↓mRNA expression levels of APN and apelin (100 µg/kg CrPic) ↓Levels of HbA1C, AGES, APN, and apelin (100 µg/kg CrPic) ↑NO and insulin levels and recover β cells function (100 µg/kg CrPic) Sundaram et al., 2013 Received 1000µg/kg of CrPic for 4 weeks ↑GSH levels and activity of antioxidant enzymes and plasma antioxidants in DM ↓Plasma glucose in DM ↓Lipid peroxidation in DM ↓Activity of AST and ALT in DM Refaie et al., 2009 Received supplementation in low (23µg/kg/day) and high doses (100 µg/kg/day) of CrPic for 4 weeks ↓FBG in diabetic in dose depend. ↔ FBG in normal rats ↑Mitochondrial β-oxidation of FFA ↑Oxidative stress in liver and brain of normal rats ↑Antioxidant system in diabetic rats ↑Total protein and [RNA] in brain and liver of normal rats with high dose of CrPic ↑Total protein in brain and liver of diabetic rats with low dose of CrPic ADP: adenosine diphosphate; AGES: advanced glycation end products; ALT: alanine transaminase; APN: adiponectin; AST: aspartate transaminase; CrPic: chromium picolinate; DM: diabetes mellitus; FBG: fasting blood glucose; FFA: free fatty acids; HbA1C: glycated hemoglobin; NO: nitric oxide; TX B2: thromboxane B2. Bruna Marmett et al. Effects of Chromium Picolinate Supplementation on Control of Metabolic Variables: A Systematic Review. Journal of Food and Nutrition Research, 2016, Vol. 4, No. 10, 633-639. doi:10.12691/jfnr-4-10-1 © The Author(s) 2015. Published by Science and Education Publishing.