Mite allergen–specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin

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Mite allergen–specific IgE is detectable in bronchial secretions of patients with nonatopic asthma and correlates with mucosal expression of periostin Jonathan Mouthuy, PhD, Sophie Viart, PhD, Maha Z. Ladjemi, PhD, Bruno Detry, MSc, Monique Henket, MSc, Claus Bachert, MD, PhD, Renaud Louis, MD, PhD, Charles Pilette, MD, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 6, Pages 1685-1688.e2 (December 2015) DOI: 10.1016/j.jaci.2015.07.018 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, D pteronyssinus–specific IgE antibodies in sputum from patients with nonatopic (n = 34) or atopic (n = 77) asthma and sputum from nonatopic control subjects (n = 14). Lines depict medians and ranges. B, Sputum eosinophils (percentage of total leukocytes) from patients with nonatopic or atopic asthma versus nonatopic control subjects. Lines depict medians and ranges. Data were obtained from 39 patients with intrinsic asthma, 89 patients with atopic asthma, and 21 control subjects. C, Periostin levels as assessed in DPBS sputum samples in patients with nonatopic (n = 33) and atopic (n = 79) asthma versus nonatopic control subjects (n = 21). Lines depict medians (interquartile ranges). D, Correlation between sputum levels of periostin and D pteronyssinus-specific IgE. Data were obtained for 114 of 149 subjects (r = 0.37, P < .0001), with 35 samples being lower than the detection limit (data not shown) for D pteronyssinus-specific IgE or periostin (0.75 ng/mL). *P < .05 and ***P < .001. Journal of Allergy and Clinical Immunology 2015 136, 1685-1688.e2DOI: (10.1016/j.jaci.2015.07.018) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Periostin release (during culture for 48 hours) by human airway epithelial cells (AECs) on recombinant IL-13 stimulation (10 ng/mL every other day) versus control (medium alone) values in the basolateral and apical compartments, as assessed at weeks 2, 3, and 4 in air-liquid conditions. Data are from AECs of 14 different donors. Lines depict medians (interquartile ranges). *P < .05. Journal of Allergy and Clinical Immunology 2015 136, 1685-1688.e2DOI: (10.1016/j.jaci.2015.07.018) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions