Fig. 2 Neonatal ZIKV infection induces seizures in young mice and increases susceptibility to chemically induced seizures in adult mice. Neonatal ZIKV.

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Fig. 2 Neonatal ZIKV infection induces seizures in young mice and increases susceptibility to chemically induced seizures in adult mice. Neonatal ZIKV infection induces seizures in young mice and increases susceptibility to chemically induced seizures in adult mice. (A) Percentage of ZIKV-infected animals with seizures in each litter (n = 4 litters per time point). (B) Representative electroencephalographic recordings obtained from one mock-infected mouse at 12 dpi. (C to K) Representative electroencephalographic recordings performed in brains of ZIKV-infected mice at 12 dpi (n = 2 mock and n = 4 ZIKV). (L to O) Time to first seizure and number of seizures for male [(L and M); n = 7 mock and n = 5 ZIKV] and female [(N and O); n = 7 mock and n = 6 ZIKV] mice after an intraperitoneal injection of PTZ at 100 to 110 dpi. Data are expressed as means ± SEM. In (L), *P = 0.0155; in (M), *P = 0.0962; in (N), *P = 0.0154; in (O), *P = 0.0008; ZIKV versus mock, Student’s t test. L1 and L2, electrodes in left hemisphere; R1 and R2, electrodes in right hemisphere. Isis Nem de Oliveira Souza et al., Sci Transl Med 2018;10:eaar2749 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works