Increased levels of acetylated histone H3 are observed in normal PBMCs and circulating tumor cells obtained from patients post-depsipeptide treatment.

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Increased levels of acetylated histone H3 are observed in normal PBMCs and circulating tumor cells obtained from patients post-depsipeptide treatment. Increased levels of acetylated histone H3 are observed in normal PBMCs and circulating tumor cells obtained from patients post-depsipeptide treatment. Whole-cell lysates of PBMCs (5 μg) were subjected to SDS-PAGE and transferred to polyvinylidene difluoride membranes. The membranes were probed with anti–glyceraldehyde-3-phosphate dehydrogenase antibody (GAPDH), stripped with 0.2 mol/L NaOH, and probed with anti-acetylated histone H3 antibody (AcH3). Samples were collected from (A) cycles 1 and 23, (B) and (C) cycle 1, (D) cycle 12, and (E) cycle 13. Robert W. Robey et al. Clin Cancer Res 2006;12:1547-1555 ©2006 by American Association for Cancer Research