Clinical Microbiology and Infection

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Presentation transcript:

Clinical Microbiology and Infection A systematic review and meta-analysis of patient data from the West Africa (2013–16) Ebola virus disease epidemic A.M. Rojek, A. Salam, R.J. Ragotte, E. Liddiard, A. Elhussain, A. Carlqvist, M. Butler, N. Kayem, L. Castle, L.'O. Odondi, K. Stepniewska, P.W. Horby Clinical Microbiology and Infection DOI: 10.1016/j.cmi.2019.06.032 Copyright © 2019 The Authors Terms and Conditions

Fig. 1 Summary of article selection process. Clinical Microbiology and Infection DOI: (10.1016/j.cmi.2019.06.032) Copyright © 2019 The Authors Terms and Conditions

Fig. 2 Meta-analysis of proportion of individuals with Ebola virus disease (EVD) presenting with a symptom compared with reference data. Blue represents a meta-analysis estimate with low or moderate heterogeneity for the pooled estimate, red represents a meta-analysis estimate with high heterogeneity. Grey is WHO reference data. All estimates are shown with their 95% CI. Clinical Microbiology and Infection DOI: (10.1016/j.cmi.2019.06.032) Copyright © 2019 The Authors Terms and Conditions

Fig. 3 Meta-analysis of the relative risk of death in individuals with Ebola virus disease (EVD) presenting with a symptom on admission, compared with symptom absence, and showing comparison reference data. Blue represents a meta-analysis estimate with low or moderate heterogeneity for the pooled estimate, red represents a meta-analysis estimate with high heterogeneity. Grey is WHO reference data. All estimates are shown with their 95% CI. Clinical Microbiology and Infection DOI: (10.1016/j.cmi.2019.06.032) Copyright © 2019 The Authors Terms and Conditions

Fig. 4 Funnel plot of case fatality rate (CFR) by country. The horizontal red line is a reference value that depicts the overall CFR for hospitalized patients during the outbreak reported by WHO, with 95% and 99.8% CI. Clinical Microbiology and Infection DOI: (10.1016/j.cmi.2019.06.032) Copyright © 2019 The Authors Terms and Conditions

Fig. 5 Reporting of predictors of mortality for patients with laboratory confirmed Ebola virus disease (EVD). Cells with a red tab reflect a complex relationship (such as statistical significance for only a subset of data). Asterisk indicates the it includes if association on univariate analysis is not supported by multivariate analysis. VL, viral load; Ct, cycle threshold; Rx, treatment. Clinical Microbiology and Infection DOI: (10.1016/j.cmi.2019.06.032) Copyright © 2019 The Authors Terms and Conditions