Supplementary Fig. 1.

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Supplementary Fig. 1

Supplementary Fig. 2 H1048 Dox (2h) - + + + + Time after Dox (h) - 0 1 3 5 Monoub p53 Higher exposure of Fig. 2a p53

* Supplementary Fig. 3 Monoub p53 p53 Actin a. WI38 b. WI38 - - + + + Dox (2h) Caffeine Pcmv bam 273H MDM2 Hrs after dox pulse - + + + - - + + + - - + + + Dox (2h) Caffeine Pcmv bam 273H MDM2 Time after dox (h) - - - - - - + + + + + + - - - - - - - - - + + + + + + - - - - - + - - - - - + + + + + - - - - - - - - - - + + + + + - + + + + + - - - - - + + + + - + + + + - + + + + + - + + + + + - - - - - + + + + - + + + + - - 0 1 3 5 - - 0 1 3 5 - 2 3 5 - - 2 3 5 - - 2 3 5 Monoub Mutp53 Monoub p53 * Mutp53 p53 Actin Actin p-Ser15 p53 c. WI38 Hsp70 Dox (2h) 273H 273HSer15A MDM2 Time after dox (h) - + + + - + + + - + + + - - - - + + + + - - - - - - - - - - - - + + + + - - - - + + + + + + + + - 0 3 5 - 0 3 5 - 0 3 5 Monoub p53 p53 * Actin

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Supplementary Fig. 10 ABC1 H1048 H1048 a. No color GFP 0h GFP 3h shMdm2 0h shMdm2 3h p53 level 110 83 55 28 134 101 67 34 121 91 60 30 Count ABC1 b. 100 102 103 104 105 100 102 103 104 105 No color No caffeine 7h caffeine H1048 p53 level 101 102 103 104 105 254 191 127 64 Count p53 level 101 102 103 104 105 213 159 106 53 Count No color 7h caffeine + MG132 H1048

a. Supplementary Fig. 11 d. H1975 U2OS b. MDA MB 231 c. WI38 Caffeine No color -101 102 103 104 105 p53 level No caffeine Caffeine H1975 Count 525 394 262 131 p53 level No color No caffeine Caffeine U2OS -101 102 103 104 105 111 83 55 28 Count b. MDA MB 231 -101 102 103 104 105 p53 level 462 346 231 115 Count No color No caffeine Caffeine WI38 p53 level 101 102 103 104 105 230 173 115 58 Count c. No color No caffeine 7h caffeine

Supplementary Fig. 12 H1048 control siRNA + - ATM siRNA - + ATM Actin