Fig. 3 DUB proteins act at different levels of type I IFN pathways.

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Fig. 3 DUB proteins act at different levels of type I IFN pathways. DUB proteins act at different levels of type I IFN pathways. (A) Luciferase activity in 293T cells transfected with an IFN-β luciferase reporter, together with vectors for RIG-I (2CARD), MAVS, cGAS/STING, TBK1, and IRF3 (5D), along with an empty vector or with expression vectors for the indicated DUBs. Columns are colored by significance relative to EV (empty vector) control (t test); color scale is given in the figure. (B) Heat map summary of (A). Negative regulations are marked green, positive regulations are marked red, and nonsignificant (NS) changes are marked gray. (C) Summary of interactions between DUBs and key molecules in type I IFN signaling pathways. (D to I) Coimmunoprecipitation and immunoassay of extracts of A549 cells infected with or without SeV (MOI, 0.1) for 12 hours with the indicated antibodies. IgG, immunoglobulin G. (J and K) Coimmunoprecipitation and immunoassay of extracts of A549 cells infected with or without HSV-1 (MOI, 0.1) for 12 hours with the indicated antibodies. (L) Coimmunoprecipitation and immunoassay of extracts of A549 cells infected with or without SeV (MOI, 0.1) for 12 hours with the indicated antibodies. (M) Summary of multilayered regulations of DUBs, according to the combination of inhibitory function levels and endogenous protein interactions. Data are representative of three independent experiments [mean and SEM in (A)]. IP, immunoprecipitate; IB, immunoblot; WCL, whole cell lysate. Qingxiang Liu et al. Sci Adv 2018;4:eaar2824 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).