Crebbp deficiency accelerates B-cell lymphoma development in mice.

Slides:

Advertisements

Similar presentations

Respiration 2012;83:74–80 - DOI: /

Advertisements

Resveratrol modulates DSS-induced neutrophils during colitis.

Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma

Dissecting p53 tumor suppressor functions in vivo

by Hyung-Gyoon Kim, Kyoko Kojima, C. Scott Swindle, Claudiu V

Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like.

Depletion of CD169+ cells leads to increased expression of CD25 on enterotoxin A–specific Vβ3+ T cells. Depletion of CD169+ cells leads to increased expression.

Attenuated MDSC-suppressive activity and metastasis development in IDO-deficient mice is rescued by IL-6. Attenuated MDSC-suppressive activity and metastasis.

Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.

Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent manner. Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent.

Effects of AG-221 treatment on survival and cell differentiation in an IDH2R140Q primary human AML xenograft model. Effects of AG-221 treatment on survival.

DNA Damage-Mediated Induction of a Chemoresistant Niche

Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.

Validation of St6GalNAc2 as a metastasis suppressor gene.

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

IFN-γ activates the fibrinolytic system.

DNA Damage-Mediated Induction of a Chemoresistant Niche

Kaplan–Meier survival curves of all-cause mortality in patients with idiopathic pulmonary fibrosis (IPF). Kaplan–Meier survival curves of all-cause mortality.

FGF-2 signaling mediates expansion of HSPCs

VAY-736 combines effectively with ibrutinib in vivo.

RNF2 overexpression promotes invasion and metastasis in a catalytic activity–dependent manner. RNF2 overexpression promotes invasion and metastasis in.

In vivo validation of effects of combination therapies on subpopulation composition. In vivo validation of effects of combination therapies on subpopulation.

Deletion of Crebbp in the GC cooperates with BCL2 deregulation to promote lymphomagenesis. Deletion of Crebbp in the GC cooperates with BCL2 deregulation.

Volume 13, Issue 6, Pages (November 2015)

Kevin G. Haworth, Christina Ironside, Zachary K. Norgaard, Willimark M

CXCR5 expression accelerates Eμ-Tcl1 leukemogenesis and is indispensable for tumor cell recruitment to lymphoid B-cell follicles. CXCR5 expression accelerates.

Anti-CD96 combines with anti–CTLA-4 or anti–PD-1 to suppress experimental and spontaneous lung metastases. Anti-CD96 combines with anti–CTLA-4 or anti–PD-1.

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

ILK knockdown increases the survival of PKD mice.

Development of human T-cell subsets in NSG hL-7xhIL-15 humanized mice.

The 3′F allele does not recapitulate the systemic hyperimmune phenotypes associated with mir-146a deficiency. The 3′F allele does not recapitulate the.

IL-10R-deficient macrophages secrete IL-23, inducing IL-22 secretion by ILC3 and TH17 cells. IL-10R-deficient macrophages secrete IL-23, inducing IL-22.

IFN-γ antagonizes TGF-β in vivo.

CD160 on CD8+ T cells is required for optimal clearance of L

Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts.

L-ICON1 is effective for the treatment of murine TNBC (4T1/Luc + GFP) in an orthotopic CDX model. L-ICON1 is effective for the treatment of murine TNBC.

c-Rel expression in donor T cells is increased after allo-HSCT.

Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.

Dox administration was required for Tet-CD19CAR T cells to show a suppressive function against a CD19+ tumor in vivo. Dox administration was required for.

Increased CCL5 expression, infiltration of Treg cells, and apoptosis of CD8+ T cells in human colorectal tissues. Increased CCL5 expression, infiltration.

Reduced tumor growth in CCR5-deficient mice is associated with perturbed killing ability of Treg cells. Reduced tumor growth in CCR5-deficient mice is.

GC reaction is impaired in NOTCH2 knock-in mice.

Progastrin expression in colonic tissues and Kaplan–Meier survival curves. Progastrin expression in colonic tissues and Kaplan–Meier survival curves. A,

Volume 33, Issue 1, Pages (July 2010)

A, Overall survival of patients treated with CAR T cells (black line; n = 15). A, Overall survival of patients treated with CAR T cells (black line; n.

CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated with a longer survival. CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated.

Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs.

Volume 17, Issue 6, Pages (June 2009)

IDO deficiency delays the development of pulmonary metastases.

Increase in proliferation and activation of immune cells in peripheral blood after NKTR-214 treatment. Increase in proliferation and activation of immune.

STINGa enhances mAb immunotherapy in BCL1 lymphoma in an FcγR-dependent manner. STINGa enhances mAb immunotherapy in BCL1 lymphoma in an FcγR-dependent.

GM-CSF is required for CA-MSC–induced tumor metastasis.

CREBBP loss-of-function results in gene expression repression signature. CREBBP loss-of-function results in gene expression repression signature. A–D,

Fig. 6 Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9 in vivo. Antitumor effect on tumor growth and pulmonary metastasis of CSSD-9.

Loss of HDAC3 inhibits CREBBP-mutant lymphoma growth in vitro and in vivo. Loss of HDAC3 inhibits CREBBP-mutant lymphoma growth in vitro and in vivo. A,

PLX51107 demonstrates in vivo antitumor effects in a preclinical model of aggressive leukemia/lymphoma. PLX51107 demonstrates in vivo antitumor effects.

Mice treated with DC therapy and/or M-CSFR inhibition were protected from tumor rechallenge with combination therapy-treated mice displaying superior recall.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

The PI3Kβ inhibitor enhances the antitumor activity of T cell–mediated immunotherapy in mice bearing PTEN loss tumors. The PI3Kβ inhibitor enhances the.

Constitutive expression of JAK3M511I and HOXA9 leads to development of both AML and T-ALL in vivo. Constitutive expression of JAK3M511I and HOXA9 leads.

Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. A,

CREBBP regulates antigen processing and presentation gene enhancers.

Volume 37, Issue 2, Pages (August 2012)

The effect of βAR signaling on the generation of a cytotoxic CD8+ T-cell response in vivo. The effect of βAR signaling on the generation of a cytotoxic.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

Expression of TGFβ ligands in GBM

ARQ 531 improves survival in the Eμ-TCL1 engraftment model compared with ibrutinib. ARQ 531 improves survival in the Eμ-TCL1 engraftment model compared.

Depletion of CD8+, CD4+, and Ly6G+ cells in subcutaneous TUBO tumor-bearing BALB/c mice treated with KM100 + MTX. Depletions were conducted by intraperitoneal.

EC-derived SP cells are targeted by CD30.CAR T cells.

Inhibition of MCL1 reduces AML in an in vivo murine model.

Presentation transcript:

Crebbp deficiency accelerates B-cell lymphoma development in mice. Crebbp deficiency accelerates B-cell lymphoma development in mice. A, Kaplan–Meier curve of C57BL/6 mice transplanted with VavP-Bcl2 HPCs transduced with MSCV-GFP retroviral vector alone (GFP, black, n = 31), or containing shRNAs against Crebbp (red, n = 34). Statistical significance of survival difference was determined by the log-rank test between shCrebbp and vector alone. B, Representative flow cytometry histograms showing the GFP-positive cell percentage of the preinjection HPCs and the splenic murine lymphoma cells that derived from the same HPCs. C, Dot plot representing the GFP-positive cell percentage in the splenic murine lymphoma cells in individual recipient animal. The mean and SEM were represented for each transplant group. Statistical significance was determined by Mann–Whitney test. D, Hematoxylin and eosin (H&E), B220, CD3, and Ki67 staining of spleen tissues extracted from recipient mice upon sacrifice. E, H&E and B220 staining of kidney and lung tissues extracted from recipient mice upon sacrifice. Yanwen Jiang et al. Cancer Discov 2017;7:38-53 ©2017 by American Association for Cancer Research