Figure 1 Relationships between genetic variants, quantitative traits and diseases Figure 1 | Relationships between genetic variants, quantitative traits.

Slides:



Advertisements
Similar presentations
Figure 1 Framework for variant interpretation of phaeochromocytomas and/or paragangliomas (PPGLs) susceptibility genes into five classes based on the likelihood.
Advertisements

Nat. Rev. Nephrol. doi: /nrneph
Nat. Rev. Nephrol. doi: /nrneph
Figure 5 A layered approach to the follow-up of patients with acute kidney disease (AKD) Figure 5 | A layered approach to the follow-up of patients with.
Figure 6 Effects of adiponectin on podocyte function
Figure 4 The theoretical contribution of genetic and
Figure 5 Inter-relationships between sleep apnoea, CKD and brain injury Figure 5 | Inter-relationships between sleep apnoea, CKD and brain injury. In chronic.
Figure 3 Energy metabolism regulation, cardiovascular and bone disease in CKD Figure 3 | Energy metabolism regulation, cardiovascular and bone disease.
Figure 3 Angiotensin signalling in adiporenal crosstalk
Figure 4 Interactions between adipose, the microbiome and kidney
Nat. Rev. Nephrol. doi: /nrneph
Figure 1 Mechanisms of kidney injury in the setting of obesity
Figure 1 Types of coronary artery calcification
Figure 2 Proinflammatory mechanisms in CKD
Figure 1 The epigenetic landscape mediates the interplay between stressors and renal dysfunction Figure 1 | The epigenetic landscape mediates the interplay.
Nat. Rev. Nephrol. doi: /nrneph
Figure 1 The genomic nephrology workflow: genetic diagnosis and clinical application Figure 1 |The genomic nephrology workflow: genetic diagnosis and clinical.
Nat. Rev. Nephrol. doi: /nrneph
Figure 1 Evolution of genetic concepts underlying risk of cardiovascular disease Figure 1 | Evolution of genetic concepts underlying risk of cardiovascular.
Figure 6 The bioavailability of phosphate differs according to the protein source Figure 6 | The bioavailability of phosphate differs according to the.
Figure 7 The efficacy of phosphate-binder therapy
Figure 3 Putative actions of glucagon-like peptide 1 (GLP-1)
Nat. Rev. Nephrol. doi: /nrneph
Figure 1 Metabolic profiling as a tool for studying rheumatic diseases
Nat. Rev. Endocrinol. doi: /nrendo
Figure 2 The network of chronic diseases and their mutual influences
Figure 2 Three distinct mechanisms of activation of
Figure 1 The burden of chronic kidney disease (CKD)
Figure 3 Societal costs for the care of patients with chronic kidney disease in the UK Figure 3 | Societal costs for the care of patients with chronic.
Nat. Rev. Nephrol. doi: /nrneph
Nat. Rev. Nephrol. doi: /nrneph
Figure 1 Sequential impact of diabetes platforms, genetic backgrounds and accelerators on albuminuria and kidney pathology in mouse models of diabetic.
Figure 1 Acute kidney injury and chronic kidney disease
Figure 4 The gut–kidney axis, inflammation and cardiovascular disease in CKD Figure 4 | The gut–kidney axis, inflammation and cardiovascular disease in.
Figure 4 Model of changes in the serum levels
Figure 1 Allele frequency and effect size for ALS-associated genes
Nat. Rev. Nephrol. doi: /nrneph
Figure 5 Potential roles of phosphate and fibroblast growth factor 23 (FGF-23) in the development of cardiovascular disease in patients with chronic kidney.
Figure 3 Statistical approaches for the analysis of metabolomic data
Figure 2 Endocrine dysfunction in mitochondrial disease and their associated gene defects Figure 2 | Endocrine dysfunction in mitochondrial disease and.
Nat. Rev. Nephrol. doi: /nrneph
Nat. Rev. Nephrol. doi: /nrneph
Figure 3 Genetic pleiotropy in ALS
Nat. Rev. Nephrol. doi: /nrneph
Nat. Rev. Nephrol. doi: /nrneph
Nat. Rev. Nephrol. doi: /nrneph
So Many Correlated Tests, So Little Time
Nat. Rev. Nephrol. doi: /nrneph
Figure 5 The nephron-centric model of renal transplant fibrosis based on the injury-related molecular events observed in biopsy samples in the first year.
Nat. Rev. Nephrol. doi: /nrneph
Antonio Julià  Journal of Investigative Dermatology 
Figure 3 Serum phosphate level is associated with
Nat. Rev. Nephrol. doi: /nrneph
Figure 3 Regulation of TGF-β1/Smad signalling by microRNAs (miRs) in tissue fibrosis Figure 3 | Regulation of TGF-β1/Smad signalling by microRNAs (miRs)
Figure 1 The relationship between health fitness and pathogen load
Nat. Rev. Nephrol. doi: /nrneph
Figure 2 Sources of data to characterize the ADPKD clinical phenotype
Figure 1 Mechanistic classification of lncRNAs
Nat. Rev. Nephrol. doi: /nrneph
Figure 2 Biologics that target CD4+ T helper (TH)-cell subsets
Figure 1 Patient, facility, health-care system and industry factors
Figure 3 Preventive strategies for CSA-AKI
Figure 4 The relationship between the time-dependent changes in the expression of immunoglobulin, mast cell, acute kidney injury (AKI), and fibrillar collagen.
Figure 4 Intracellular distribution and
Figure 1 Worldwide distribution of disease burden attributable to environmental risks in 2012 Figure 1 | Worldwide distribution of disease burden attributable.
Figure 2 Phenotypes of osteoarthritis
Tracking Family History
David B. Allison, Bonnie Thiel, Pamela St. Jean, Robert C
Unified Sequence-Based Association Tests Allowing for Multiple Functional Annotations and Meta-analysis of Noncoding Variation in Metabochip Data  Zihuai.
Nat. Rev. Nephrol. doi: /nrneph
Presentation transcript:

Figure 1 Relationships between genetic variants, quantitative traits and diseases Figure 1 | Relationships between genetic variants, quantitative traits and diseases. A single genetic variant may be associated with multiple traits, and genetic variants of multiple genes may be associated with a single trait. Similarly, a disease can be associated with single or multiple traits. Correlations between traits and diseases may provide predictive power and serve as the basis for further studies to investigate disease pathogenesis. Mattson, D. L. (2018) An integrated genetic analysis of disease Nat. Rev. Nephrol. doi:10.1038/nrneph.2018.26