Candesartan diminishes SynO-mediated morphofunctional responses in microglia. Candesartan diminishes SynO-mediated morphofunctional responses in microglia.

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Candesartan diminishes SynO-mediated morphofunctional responses in microglia. Candesartan diminishes SynO-mediated morphofunctional responses in microglia. (A) Iba-1 immunocytochemistry (red) of microglia pretreated with 10, 20, or 30 μM candesartan cilexetil (CD) or vehicle (equivalent to 30 μM CD) for 2 hours and subsequently exposed to SynO (8.0 ng/ml) or buffer for 12 hours. Cell nuclei were stained with DAPI (blue). Scale bars, 20 μm. (B) ELISA for the concentration of TNF-α in conditioned medium of microglia treated as in (A). Data are means ± SEM (n = 3). *P = 0.01, **P = 0.001, comparing 10, 20, or 30 μM conditions to vehicle + SynO by one-way ANOVA with Bonferroni post hoc test. Stefano G. Daniele et al., Sci. Signal. 2015;8:ra45 Copyright © 2015, American Association for the Advancement of Science