Patient 2: 3-year-old girl with leukokoria, red and painful eye, vitreous opacities, total retinal detachment, and neovascularization of the iris. Patient.

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Presentation transcript:

Patient 2: 3-year-old girl with leukokoria, red and painful eye, vitreous opacities, total retinal detachment, and neovascularization of the iris. Patient 2: 3-year-old girl with leukokoria, red and painful eye, vitreous opacities, total retinal detachment, and neovascularization of the iris. A, Sonogram shows detachment and thickening of the retina with two hyperreflective micronodules (arrowheads).B and C, Unenhanced (B) and enhanced (C) T1-weighted MR images show retinal detachment with frankly hyperintense subretinal space as compared with the vitreous (arrow, B) and locally nodular enhancement (arrow, C) of detached retinal leaflets.D and E, T2-weighted MR images show detached retina with localized thickening and relatively low signal intensity (arrows).F and G, Low- (F) and high-power (G) histologic sections show retinoblastoma with infiltrating (arrow, G) and endophytic (arrow, F) components predominantly involving the temporal territory (hematein-eosin-saffron stain, original magnifications ×2 and ×25, respectively). (Box in F denotes magnified area in G.)‏ Hervé J. Brisse et al. AJNR Am J Neuroradiol 2001;22:499-504 ©2001 by American Society of Neuroradiology