A. Levillain, C. Boulocher, S. Kaderli, E. Viguier, D. Hannouche, T

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Presentation transcript:

Meniscal biomechanical alterations in an ACLT rabbit model of early osteoarthritis A. Levillain, C. Boulocher, S. Kaderli, E. Viguier, D. Hannouche, T. Hoc, H. Magoariec Osteoarthritis and Cartilage Volume 23, Issue 7, Pages 1186-1193 (July 2015) DOI: 10.1016/j.joca.2015.02.022 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Sample preparation procedure: A) optical image of a right lateral meniscus (contralateral) and localization of the two studied regions B) first cutting plane (the radial plane is hatched) and representation of the circumferential direction, C) second cutting plane (the tibial plane is hatched) and representation of the vertical direction. Osteoarthritis and Cartilage 2015 23, 1186-1193DOI: (10.1016/j.joca.2015.02.022) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Typical indentation curves of contralateral (black) and operated (grey) menisci. The dotted line represents the tangent (i.e., Slope S) to the curve at the initial point of the unloading part. Osteoarthritis and Cartilage 2015 23, 1186-1193DOI: (10.1016/j.joca.2015.02.022) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Raman spectra of contralateral and operated menisci in medial and lateral sites. Presence of the main collagen bands. Absence of the crystal bands (HA, CPPD). Osteoarthritis and Cartilage 2015 23, 1186-1193DOI: (10.1016/j.joca.2015.02.022) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Circumferential collagen fibers arrangement in A) medial and B) lateral contralateral menisci. The arrow indicates the radial direction, corresponding to the x-axis, and is oriented towards the center of the meniscus. Images' size: 509.12 μm × 509.12 μm × 150 μm. Osteoarthritis and Cartilage 2015 23, 1186-1193DOI: (10.1016/j.joca.2015.02.022) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Circumferential collagen fibers arrangement in A) medial and B) lateral operated menisci. The arrow indicates the radial direction, corresponding to the x-axis, and is oriented towards the center of the meniscus. Images' size: 509.12 μm × 509.12 μm × 200 μm. Osteoarthritis and Cartilage 2015 23, 1186-1193DOI: (10.1016/j.joca.2015.02.022) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Representative images of SOFG staining in A) contralateral (Cont.) and B) operated (Op.) menisci. The sections correspond to the same animal. Boxes indicate the location of the following detail images; C) (C in B) close-up of an intensely stained area. Collagen fibers were highly undulated and not well aligned; D) (D in B) close-up of a weakly stained area. Collagen fibers were straighter and less unorganized; E) mean percent area of GAG coverage and SD bars (n = 3). * corresponds to P < 0.05. Osteoarthritis and Cartilage 2015 23, 1186-1193DOI: (10.1016/j.joca.2015.02.022) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions