Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet Jonathan M. Spergel, MD, PhD, Terri F. Brown-Whitehorn,

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Presentation transcript:

Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet Jonathan M. Spergel, MD, PhD, Terri F. Brown-Whitehorn, MD, Antonella Cianferoni, MD, PhD, Michele Shuker, RD, Mei-Lun Wang, MD, Ritu Verma, MD, Chris A. Liacouras, MD Journal of Allergy and Clinical Immunology Volume 130, Issue 2, Pages 461-467.e5 (August 2012) DOI: 10.1016/j.jaci.2012.05.021 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Patients with EoE identified in the study. Patients with gastroesophageal reflux disease (GERD), eosinophilic gastroenteritis (EG), or eosinophilic colitis (EC) or being treated with swallowed corticosteroids (CS) or anti–IL-5 were excluded. The patients with foods identified based on addition or removal of a single food were defined as the definitive food cohort. Journal of Allergy and Clinical Immunology 2012 130, 461-467.e5DOI: (10.1016/j.jaci.2012.05.021) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Percentage of patients with EoE with 1, 2, 3, or 4 or more food allergies in the definitive food cohort. Food or foods were identified based on changes in esophageal biopsy specimens from normal to abnormal (>15 eosinophils/hpf) after addition of a single food or normalization of esophageal biopsies (0 eosinophils/hpf) after removal of a single food. Age of diagnosis was expressed as mean ± SEM values. Journal of Allergy and Clinical Immunology 2012 130, 461-467.e5DOI: (10.1016/j.jaci.2012.05.021) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Success rate of various diet therapies in patients with EoE. Retrospective examination of various diets in the EoE definitive food cohort patients (319 patients). Diet successes were defined as identification of all of the causative foods in patients with EoE that led to normalization of esophageal biopsy specimens. Journal of Allergy and Clinical Immunology 2012 130, 461-467.e5DOI: (10.1016/j.jaci.2012.05.021) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions