IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis Janine Bilsborough, PhD, Donald.

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Presentation transcript:

IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis Janine Bilsborough, PhD, Donald Y.M. Leung, MD, PhD, Mark Maurer, BS, Michael Howell, PhD, Mark Boguniewcz, MD, Lena Yao, PhD, Harold Storey, BS, Cosette LeCiel, MS, Brandon Harder, BS, Jane A. Gross, PhD Journal of Allergy and Clinical Immunology Volume 117, Issue 2, Pages 418-425 (February 2006) DOI: 10.1016/j.jaci.2005.10.046 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 IL-31RA in skin biopsy specimens from patients with AD (A) compared with healthy individuals (B) was determined by means of IHC (40× magnification). Immunofluorescent costaining of infiltrating cells present in skin biopsy specimens from patients with AD with IL-31RA and CD3 (C) or CD68 (D) is shown. These data are representative of skin biopsy specimens from 5 individual patients with AD and 3 healthy individuals (Table I). Journal of Allergy and Clinical Immunology 2006 117, 418-425DOI: (10.1016/j.jaci.2005.10.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 CD3+ T cells in skin biopsy specimens from patients with AD (A) compared with healthy individuals (B). CLA+ cells in skin biopsy specimens from patients with AD (C) compared with that in skin from healthy individuals (D; 40× magnification) are shown. These data are representative of skin biopsy specimens from 5 individual patients with AD and 3 healthy individuals (Table I). Journal of Allergy and Clinical Immunology 2006 117, 418-425DOI: (10.1016/j.jaci.2005.10.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 IL-31 mRNA in the epidermal keratinocyte layer (Epi) and infiltrating cells (Inf) of skin biopsy specimens from patients with AD (A) or the epidermal keratinocyte layer of healthy individuals (B) is shown. Water was included as a negative control. M, Molecular weight markers. C, Semiquantitative analysis of IL-31 mRNA gene expression relative to an internal housekeeping gene, HPRT (IL-31/HPRT), is shown. Journal of Allergy and Clinical Immunology 2006 117, 418-425DOI: (10.1016/j.jaci.2005.10.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 CLA+ and CLA− T cells from 6 patients with AD and 6 healthy individuals were stimulated for 0, 4, or 24 hours with anti-CD3 and anti-CD28. IL-31 mRNA was assayed by means of quantitative PCR (A), and culture supernatants were analyzed for IL-31 (B). Statistical analysis was done with the nonparametric Mann-Whitney U test. Journal of Allergy and Clinical Immunology 2006 117, 418-425DOI: (10.1016/j.jaci.2005.10.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 CLA+ T cells from 12 patients with AD, 6 patients with psoriasis (Ps), and 12 healthy individuals were stimulated with a suboptimal concentration of anti-CD3 alone for 24 hours. Culture supernatants were collected, and IL-31 protein levels were assessed. Samples below the limit of detection were designated as 0 pg/ml IL-31. Journal of Allergy and Clinical Immunology 2006 117, 418-425DOI: (10.1016/j.jaci.2005.10.046) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions