Effect of siltuximab on paclitaxel sensitivity in ovarian cancer drug resistant cells. Effect of siltuximab on paclitaxel sensitivity in ovarian cancer.

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Effect of siltuximab on paclitaxel sensitivity in ovarian cancer drug resistant cells. Effect of siltuximab on paclitaxel sensitivity in ovarian cancer drug resistant cells. SKOV-3TR and Caov-3TR cells at 2 × 103 cells per well were plated in 96-well plates in culture medium containing different concentrations of siltuximab and paclitaxel. After 96 hours of culture, effect of siltuximab on paclitaxel-induced cell death were determined by MTT assay as described in Materials and Methods. A, Effect of siltuximab on paclitaxel sensitivity in SKOV-3TR. C, Effect of siltuximab on paclitaxel sensitivity in Caov-3TR. Statistical analysis was performed by a 2-sided Student's t-test in SKOV-3TR (B) and Caov-3TR (D). Cell viability was assessed using the MTT and recorded as percent viability relative to the untreated control cells. Error bars are SD of averaged results and P < 0.05 were accepted as a significant difference between means. Values are representative of triplicate determinations in 2 or more experiments. Yuqi Guo et al. Clin Cancer Res 2010;16:5759-5769 ©2010 by American Association for Cancer Research