Signaling pathways of galanin receptors.

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Signaling pathways of galanin receptors. Signaling pathways of galanin receptors. Abbreviations: AC, adenylate cyclase; BK, calcium-activated (big) potassium channel; CaCC, calcium-dependent chloride channel; (p)CREB, (phosphorylated) 3′,5′-cAMP response element-binding protein; DAG, diacylglycerol; GIRK, G protein–regulated inwardly rectifying potassium channel; IP3, inositol triphosphate; MEK, mitogen-induced extracellular kinase; PDK-1, phosphoinosotide-dependent protein-kinase 1; PIP2, phosphatidylinositol bisphosphate; PIP3, phosphatidylinositol trisphosphate; PI3K, phosphatidylinositol 3-kinase; PKB, protein kinase B; PLC, phospholipase C; VDCC, voltage-dependent calcium channel. Roland Lang et al. Pharmacol Rev 2015;67:118-175 Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics