Antihyperglycemic therapy in adults with type 2 diabetes Antihyperglycemic therapy in adults with type 2 diabetes. *If patient does not tolerate or has contraindications to metformin, consider agents from another class in Table 8.1 of ref. 2. #GLP-1 receptor agonists and DPP-4 inhibitors should not be prescribed in combination. Antihyperglycemic therapy in adults with type 2 diabetes. *If patient does not tolerate or has contraindications to metformin, consider agents from another class in Table 8.1 of ref. 2. #GLP-1 receptor agonists and DPP-4 inhibitors should not be prescribed in combination. If a patient with ASCVD is not yet on an agent with evidence of cardiovascular risk reduction, consider adding. Reprinted with permission from the American Diabetes Association (2). Joshua J. Neumiller, and Guillermo E. Umpierrez Diabetes Spectr 2018;31:254-260 ©2018 by American Diabetes Association