Zhuxiang Nie, Takashi Hashimoto  Journal of Investigative Dermatology 

Slides:



Advertisements
Similar presentations
Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters  Artem Vorobyev, Hideyuki Ujiie, Andreas Recke,
Advertisements

The Autoantigen in Anti-p200 Pemphigoid Is Synthesized by Keratinocytes and Fibroblasts and Is Distinct from Nidogen-2  Silke C. Hofmann, Ursula Voith,
The Autoantigen of Anti-p200 Pemphigoid Is an Acidic Noncollagenous N-Linked Glycoprotein of the Cutaneous Basement Membrane  Iakov Shimanovich, Yoshiaki.
Bullous Allergic Hypersensitivity to Bed Bug Bites Mediated by IgE against Salivary Nitrophorin  Martin Leverkus, Ryan C. Jochim, Susanne Schäd, Eva-Bettina.
Bullous Pemphigoid Sera that Contain Antibodies to BPAg2 also Contain Antibodies to LABD97 that Recognize Epitopes Distal to the NC16A Domain  Conleth.
A case of childhood bullous pemphigoid with IgG and IgA autoantibodies to various domains of BP180  Manabu Osawa, MD, Ikuko Ueda-Hayakawa, MD, PhD, Taiki.
Mucous membrane pemphigoid with autoantibodies to all the laminin 332 subunits and fatal outcome resulting from liver cirrhosis and hepatocellular carcinoma 
Refractory oral ulcers with multiple immunoglobulin G/immunoglobulin A autoantibodies without skin lesions  Teruki Dainichi, MD, Bungo Ohyama, MD, Norito.
Epitopes in the Linker Subdomain Region of Envoplakin Recognized by Autoantibodies in Paraneoplastic Pemphigus Patients  Bingxin Zhang, Rui Zheng, Jing.
Prevalence of Yersinia plasmid-encoded outer protein (Yop) class-specific antibodies in patients with Hashimoto's thyroiditis  S. Chatzipanagiotou, J.N.
Takashi Hashimoto, Norito Ishii, Daisuke Tsuruta 
Xiang Ding, Luis A. Diaz, Janet A. Fairley, George J. Giudice, Zhi Liu 
C-Terminus of Desmoyokin/AHNAK Protein is Responsible for its Translocation Between the Nucleus and Cytoplasm  Zhuxiang Nie, Takashi Hashimoto  Journal.
Paraneoplastic Pemphigus Sera React Strongly with Multiple Epitopes on the Various Regions of Envoplakin and Periplakin, Except for the C-Terminal Homologous.
Anti-Desmoglein-1 Antibodies in Onchocerciasis, Leishmaniasis and Chagas Disease Suggest a Possible Etiological Link to Fogo Selvagem  Luis A. Diaz, Luis.
Autoantibodies in a Subgroup of Patients with Linear IgA Disease React with the NC16A Domain of BP1801  Detlef Zillikens, Karin Herzele, Matthias Georgi,
John J. Zone, C. Anthony Egan, Ted B. Taylor 
Demonstration of Epitope Spreading in Bullous Pemphigoid: Results of a Prospective Multicenter Study  Takashi Hashimoto, Daisuke Tsuruta, Teruki Dainichi,
Post-IID 2008 International Meeting on Autoimmune Bullous Diseases
Francois le Pelletier, Anne Janin  Journal of Investigative Dermatology 
Pharmacodynamic Effects of the Murine p75-Fc Fusion Protein in Mice
Autoantibodies to Bullous Pemphigoid Antigen 180 Induce Dermal–Epidermal Separation in Cryosections of Human Skin  Cassian Sitaru, Enno Schmidt, Steffen.
Detection of IgG Autoantibodies in the Sera of Patients with Bullous and Gestational Pemphigoid: ELISA Studies Utilizing a Baculovirus-Encoded Form of.
Epitope Spreading: Lessons From Autoimmune Skin Diseases
Clinical Snippets Journal of Investigative Dermatology
Minutes of the Board of Directors Meeting
Star Trek Publishing Journal of Investigative Dermatology
BP230- and BP180-specific Auto-Antibodies in Bullous Pemphigoid
Identification of a Potential Effector Function for IgE Autoantibodies in the Organ- Specific Autoimmune Disease Bullous Pemphigoid  Otobia G. Dimson,
Molecular Consequences of Deletion of the Cytoplasmic Domain of Bullous Pemphigoid 180 in a Patient with Predominant Features of Epidermolysis Bullosa.
Journal of Investigative Dermatology
Journal of Investigative Dermatology 
A Pathogenic Role for IgE in Autoimmunity: Bullous Pemphigoid IgE Reproduces the Early Phase of Lesion Development in Human Skin Grafted to nu/nu Mice 
Autoantibody Profile Differentiates between Inflammatory and Noninflammatory Bullous Pemphigoid  Kentaro Izumi, Wataru Nishie, Yosuke Mai, Mayumi Wada,
The Members of the Plakin Family of Proteins Recognized by Paraneoplastic Pemphigus Antibodies Include Periplakin  My G. Mahoney, Sirpa Aho, Jouni Uitto,
Society for Investigative Dermatology 2010 Meeting Minutes
BJD Editor's Choice Journal of Investigative Dermatology
The Intracellular and Extracellular Domains of BP180 Antigen Comprise Novel Epitopes Targeted by Pemphigoid Gestationis Autoantibodies  Giovanni Di Zenzo,
Decreased Serum Ferritin is Associated With Alopecia in Women
Research Snippets Journal of Investigative Dermatology
Clinical Snippets Journal of Investigative Dermatology
Journal of Investigative Dermatology
How Much Sun Protection Is Needed
IgG Autoantibodies from Bullous Pemphigoid (BP) Patients Bind Antigenic Sites on Both the Extracellular and the Intracellular Domains of the BP Antigen.
Genetic Influences on Human Body Odor: From Genes to the Axillae
Anti-Alpha-2-Macroglobulin-Like-1 Autoantibodies Are Detected Frequently and May Be Pathogenic in Paraneoplastic Pemphigus  Sanae Numata, Kwesi Teye,
Research Snippets from the British Journal of Dermatology
TLR3: A Receptor that Recognizes Cell Injury Is Essential for Permeability Barrier Homeostasis Following UV Irradiation  Kenneth R. Feingold  Journal.
Pathogenicity and Epitope Characteristics of Anti-Desmoglein-1 from Pemphigus Foliaceus Patients Expressing Only IgG1 Autoantibodies  Mary K. Hacker-foegen,
The Prevalence and Clinical Significance of Anti-U1 RNA Antibodies in Patients with Systemic Sclerosis  Yoshihide Asano, Hironobu Ihn, Kenichi Yamane,
Production of Low Titers of Anti-Desmoglein 1 IgG Autoantibodies in Some Patients with Staphylococcal Scalded Skin Syndrome  Hidemi Anzai, John R. Stanley,
Research Snippets Journal of Investigative Dermatology
Journal of Investigative Dermatology
Autoantibody in Mucous Membrane Pemphigoid Binds to an Intracellular Epitope on Human β4 Integrin and Causes Basement Membrane Zone Separation in Oral.
Autoantibodies in Vitiligo Patients Recognize Multiple Domains of the Melanin- Concentrating Hormone Receptor  Raju V.S.R.K. Gottumukkala, Elizabeth A.
Autoantibodies to BP180 Associated with Bullous Pemphigoid Release Interleukin-6 and Interleukin-8 from Cultured Human Keratinocytes  Enno Schmidt, Stanislaus.
IgG Autoantibodies from Bullous Pemphigoid Patients Recognize Multiple Antigenic Reactive Sites Located Predominantly Within the B and C Subdomains of.
Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with More Severe Dementia in Alzheimer’s Disease  Nina Kokkonen, Sanna-Kaisa.
Janet A. Fairley, Chang Ling Fu, George J. Giudice 
Immunological and Statistical Studies of Anti-BP180 Antibodies in Paraneoplastic Pemphigus  Atsunari Tsuchisaka, Hideo Kawano, Atsushi Yasukochi, Kwesi.
Detection of Laminin 5-Specific Auto-antibodies in Mucous Membrane and Bullous Pemphigoid Sera by ELISA  Vassiliki Bekou, Sybille Thoma-Uszynski, Olaf.
Severity and Phenotype of Bullous Pemphigoid Relate to Autoantibody Profile Against the NH2- and COOH-Terminal Regions of the BP180 Ectodomain  Silke.
Journal of Investigative Dermatology
Journal of Investigative Dermatology
S.J.P. Warren, L.A. Arteaga, L.A. Diaz 
Flor Evangelista, David A. Dasher, Luis A. Diaz, Phillip S
A Subset of Pemphigus Foliaceus Patients Exhibits Pathogenic Autoantibodies Against Both Desmoglein-1 and Desmoglein-3  Luis A. Arteaga, Philip S. Prisayanh,
Envoplakin and Periplakin, the Paraneoplastic Pemphigus Antigens, are also Recognized by Pemphigus Foliaceus Autoantibodies  Shideh Kazerounian, Mỹ G.
Childhood epidermolysis bullosa acquisita with autoantibodies against all 3 structural domains of type VII collagen  Takaya Fukumoto, MD, Toshiki Umekawa,
Staphylococcal Exfoliative Toxin B Specifically Cleaves Desmoglein 1
Presentation transcript:

IgA Antibodies of Cicatricial Pemphigoid Sera Specifically React with C-Terminus of BP180  Zhuxiang Nie, Takashi Hashimoto  Journal of Investigative Dermatology  Volume 112, Issue 2, Pages 254-255 (February 1999) DOI: 10.1046/j.1523-1747.1999.00501.x Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Multiple fusion proteins were recognized by IgG antibodies of both BP and CP sera, whereas C-terminal domain was reacted by IgA antibodies of only CP sera. (a) Immunoblotting for IgG and IgA antibodies using GST-BP-1050. An arrowhead indicates the positive band of intact recombinant protein;small bars indicate the degradation products. (b) Immunoblotting for IgG and IgA antibodies using GST-BP-963. (c) Immunoblotting for IgG and IgA antibodies using GST-BP-915. In (b) and (c), arrowheads indicate the positive bands of intact recombinant proteins;small bars indicate nonspecific bands. The reactivity of three BP sera, which possessed IgG antibodies reactive with all GST-BP-1050, GST-BP-963, and GST-BP-915, is shown in lanes 1, 2, and 3 in (a)–(c). The reactivity of three CP sera, which showed IgG antibodies reactive with both GST-BP-1050 and GST-BP-915, is shown in lanes 4, 5, and 6 in all parts. Among these three CP sera, one serum showed weak reactivity of IgG antibodies with the central domain. All the three CP sera are also shown to possess IgA antibodies reactive with GST-BP-915. Lane 7 in all parts shows the reactivity of a normal control serum. Journal of Investigative Dermatology 1999 112, 254-255DOI: (10.1046/j.1523-1747.1999.00501.x) Copyright © 1999 The Society for Investigative Dermatology, Inc Terms and Conditions