Phase II Trial of High-Dose Gemcitabine/Busulfan/Melphalan with Autologous Stem Cell Transplantation for Primary Refractory or Poor-Risk Relapsed Hodgkin.

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Presentation transcript:

Phase II Trial of High-Dose Gemcitabine/Busulfan/Melphalan with Autologous Stem Cell Transplantation for Primary Refractory or Poor-Risk Relapsed Hodgkin Lymphoma Yago Nieto, Peter F. Thall, Junsheng Ma, Benigno C. Valdez, Sairah Ahmed, Paolo Anderlini, Uday Popat, Roy B. Jones, Elizabeth J. Shpall, Chitra Hosing, Muzaffar Qazilbash, Partow Kebriaei, Amin Alousi, Melissa Timmons, Alison Gulbis, Alan Myers, Yasuhiro Oki, Michelle Fanale, Bouthaina Dabaja, Chelsea Pinnix, Sarah Milgrom, Richard Champlin, Borje S. Andersson Biology of Blood and Marrow Transplantation Volume 24, Issue 8, Pages 1602-1609 (August 2018) DOI: 10.1016/j.bbmt.2018.02.020 Copyright © 2018 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Prognostic stratification of Gem/Bu/Mel patients according to PET status at HDC (A) and based on the International Prognostic Score (B). Biology of Blood and Marrow Transplantation 2018 24, 1602-1609DOI: (10.1016/j.bbmt.2018.02.020) Copyright © 2018 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Comparison of outcomes in the Gem/Bu/Mel and BEAM cohorts. (A) PFS (P = .05, unstratified; P = .008, stratified for PET and DFI-6). (B) OS (P = .0008, unstratified; P = .0003, stratified for PET and DFI-6). Biology of Blood and Marrow Transplantation 2018 24, 1602-1609DOI: (10.1016/j.bbmt.2018.02.020) Copyright © 2018 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Studies of DNA damage response in peripheral blood mononuclear cells of patients receiving Gem/Bu/Mel (n = 19). (A) Cellular changes in the level of γ-H2AX levels. (B) Representative cases of decreased PARP-1 levels. Biology of Blood and Marrow Transplantation 2018 24, 1602-1609DOI: (10.1016/j.bbmt.2018.02.020) Copyright © 2018 The American Society for Blood and Marrow Transplantation Terms and Conditions