B. fragilis utilizes TLR2 signaling for its protective role against the development of colitis-associated cancer in mice. B. fragilis utilizes TLR2 signaling.

Slides:

Advertisements

Similar presentations

Ursodeoxycholic acid inhibits colonic mucosal cytokine release and prevents colitis in a mouse model of disease Joseph BJ Ward 1, Orlaith Kelly 1,2, Siobhan.

Advertisements

A 43kD protein from the herb, Cajanus indicus L

Volume 131, Issue 4, Pages (October 2006)

Binding of 53BP1 on uncapped telomeres.

Volume 25, Issue 4, Pages (April 2014)

Volume 15, Issue 2, Pages (February 2009)

Volume 23, Issue 1, Pages (January 2013)

Localization of Gammaproteobacteria and evidence of Proteobacteria migration into the crypts within the distal colon of mice inoculated with C. rodentium.

Volume 24, Issue 5, Pages (November 2013)

Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.

Volume 141, Issue 4, Pages e2 (October 2011)

Treatment of SFTSV-infected IFNAR−/− mice with T-705 or ribavirin.

BV6 increases tumor burden in bone.

Volume 40, Issue 1, Pages (January 2014)

Inhibition of FGFR signaling and tumor growth in SNU-16 xenograft model by administration of E7090. Inhibition of FGFR signaling and tumor growth in SNU-16.

Volume 20, Issue 5, Pages (November 2011)

Fig. 8 TLR8 exacerbates disease in the BLM-induced fibrosis model.

Fig. 6 pDCs infiltrate the skin of BLM-treated mice, and their depletion attenuates skin fibrosis. pDCs infiltrate the skin of BLM-treated mice, and their.

Antitumor effect of local cancer immunotherapy treatment toward distant B16F10 tumors. Antitumor effect of local cancer immunotherapy treatment toward.

Volume 129, Issue 3, Pages (September 2005)

Therapeutic effects of TIP60 allosteric modification in DSS-induced colitis. Therapeutic effects of TIP60 allosteric modification in DSS-induced colitis.

Volume 19, Issue 13, Pages (June 2017)

Volume 146, Issue 7, Pages e4 (June 2014)

Histological changes in mouse colons after DSS treatment.

Ling Zheng, Terrence E. Riehl, William F. Stenson Gastroenterology

Volume 118, Issue 2, Pages (July 2004)

High-density foci of Giardia colonization are present in the proximal small intestine of mice and gerbils. High-density foci of Giardia colonization are.

Volume 19, Issue 11, Pages (June 2017)

Role of TLR signaling in hY4-induced changes and effects of TLR inhibition. Role of TLR signaling in hY4-induced changes and effects of TLR inhibition.

Supplementary Figure 5: Effect of S48168 on normalized organ and skeletal muscle weights after 12 weeks of treatment for all the experimental groups from.

Activity of MAC-321 (i. v. and p. o

Valproic acid (VPA) prevents small cell lung carcinoma (SCLC) tumour growth in combination with cyclophosphamide, vindesine and doxorubicin. Valproic acid.

Volume 13, Issue 6, Pages (June 2013)

Antibody reactivity against HA1 proteins after vaccination.

Volume 118, Issue 2, Pages (July 2004)

Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer. Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer.

Effects of tumour size on response to treatment in the KPC model.

Glucose tolerance in WT and TRPM2-KO mice.

MRP2 inhibition mitigates pulmonary burden and bacteremia following lung challenge with S. pneumoniae. MRP2 inhibition mitigates pulmonary burden and bacteremia.

Figure 1 EAE severity and CNS pathology in Dex-treated MIF−/− and Wt mice Wild-type (Wt) and macrophage migration inhibitory factor (MIF)−/− mice were.

Prime and boosts with PBK001 vaccine provided 100% protection with low bacterial burden in organs. Prime and boosts with PBK001 vaccine provided 100% protection.

Gene expression changes associated with response to combination CPI-444 and anti–PD-L1 treatment in MC38 tumors. Gene expression changes associated with.

Effect of mitomycin C and bortezomib on the growth of LS174T intraperitoneal tumors. Effect of mitomycin C and bortezomib on the growth of LS174T intraperitoneal.

Fig. 5 Treatment with BMS (PO BID) protects from wasting and colitis in two SCID mouse models. Treatment with BMS (PO BID) protects from.

Intranasal immunization of mice with S

Inhibiting or altering the timing of microbial antigen encounter results in inflammatory T cell responses against gut bacteria and worsened colitis upon.

Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.

Tlr4−/− attenuates symptomatic parameters of gut toxicity: diarrhea and weight loss. Tlr4−/− attenuates symptomatic parameters of gut toxicity: diarrhea.

The effect of IAA on tumor growth in an SK-MEL-28 xenograft model.

Effect of therapy with S247 on the development of liver metastases after 14 and 21 days of tumor growth. Effect of therapy with S247 on the development.

LEfSe comparison analysis between the control and ciprofloxacin or vancomycin-imipenem groups at the end of antibiotic treatment (A or B, respectively)

Inflammation-induced tumorigenesis is commensal dependent.

Paclitaxel treatment along with CXCR2 knockdown reduces tumor growth and metastasis. Paclitaxel treatment along with CXCR2 knockdown reduces tumor growth.

BTK-activated signaling regulates PDAC tumorigenesis.

Influenza vaccine enhances NK cell function through IFN-α.

Activity of a chemically modified miR-21 inhibitor in human bladder cancer xenografts. Activity of a chemically modified miR-21 inhibitor in human bladder.

The CD8+ cytotoxic T-cell response in Ron TK−/− hosts in response to tumors is necessary and sufficient to block metastasis. The CD8+ cytotoxic T-cell.

Impact of eNOS expression and treatment with GSNO on prostate tumor growth. Impact of eNOS expression and treatment with GSNO on prostate tumor growth.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

Wild-type mice weight following 6-thio-dG and 6-thioguanine treatment.

Comparative effect of anti-TIM3 against experimental tumors.

TAE-684 effectively inhibits the growth of H3122 in vivo.

Efficacy of KM100 and/or MTX in BALB/c mice bearing subcutaneous TUBO tumors. Efficacy of KM100 and/or MTX in BALB/c mice bearing subcutaneous TUBO tumors.

PDL192 and inhibit the growth of xenograft tumors.

GCS-100 selectively kills KRAS-addicted lung tumors.

BV6 increases bone metastasis.

Colonization with B. fragilis protects mice against development of colon cancer. Colonization with B. fragilis protects mice against development of colon.

The tumorous pancreas has an abundant microbiome and its ablation is protective against pancreatic disease progression. The tumorous pancreas has an abundant.

Tumor growth in female progeny with prenatal/maternal, postnatal early-life, and postnatal adult BSp dietary administrations. Tumor growth in female progeny.

Parthenolide inhibits tumor promotion and increases p21 expression in vivo. Parthenolide inhibits tumor promotion and increases p21 expression in vivo.

Presentation transcript:

B. fragilis utilizes TLR2 signaling for its protective role against the development of colitis-associated cancer in mice. B. fragilis utilizes TLR2 signaling for its protective role against the development of colitis-associated cancer in mice. C57BL/6J (B6) or Tlr2−/− mice were treated orally with either PBS or B. fragilis three times a week starting a week prior to AOM injection until the end of the experiment (8 mice per group). After an initial AOM intraperitoneal injection (10 mg/kg), 2.5% DSS was administered via the drinking water for 6 days followed by administration of regular drinking water. The mice underwent a second DSS treatment cycle with 2.5% DSS-treated water on day 25 for 6 days and a third cycle with 1.5% DSS-treated water on day 55 for 4 to 6 days. The mice were sacrificed on day 81 post-AOM injection. (A) Percent weight change in the indicated groups during DSS treatment. WT, wild type. (B) Number of tumors in the total (left), proximal (middle), or distal (right) colon of the indicated groups on day 81 of AOM-DSS treatment. (C) Scores of hyperplasia (left) and dysplasia (right) from longitudinal sections of colon of the indicated groups on day 81 of AOM-DSS treatment. Data are representative of results from at least two experiments. Statistical significance was calculated using unpaired Student's t tests and nonparametric Mann-Whitney tests. *, P < 0.05; **, P < 0.005; ****, P < 0.0001 (in all panels). Yun Kyung Lee et al. mSphere 2018; doi:10.1128/mSphere.00587-18