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© The Author(s) 2013. Published by Science and Education Publishing. Table 1. Aetiology and predisposing factors contributing to complicated skin and skin structure infections (cSSSI’s) Aetiology Predisposing factors Common Bacterial causes Staphylococcus aureus Coagulase negative Staphylococci (CONS) Streptococcus pyogenes Streptococcus spp (Group B, C, G and H) Enterococcus spp Pseudomonas spp Acinetobacter spp Citrobacter spp Enterobacteriaceae members (Escherechia coli, Klebsiella spp, Proteus spp, Enterobacter spp, Serretia spp, Salmonella spp and others) Vibrio spp Aeromonas hydrophila Mycobacterium spp Clostridium spp Haemophillus influenzae Human and Animal bite/contact/ wounds Pasteurella multocida Pasteurella spp Campylobacter spp Capnocytophaga canimorsus Streptobacillus moniliformis Bartonella henselae Fransisella tularensis Bacillus anthracis Yersinia pestis Spirullum minor CDC group EF4 Vibrio carchariae Fusobacterium spp Prevotella spp Unusual bacterial causes Vibrio fluvialis Vibrio vulnificus Eikenella corrodens Nocardia spp (soil contamination) Erysipelothrix rhusiopathiae Helicobacter cinaedi Infectious diseases presenting as Skin lesions Neisseria meningitidis Streptococcus pyogenes (scarlet fever) Rickettsial infections Treponema pallidum (syphilis) Candida spp (Tinea) Cryptococcus spp (Cutaneous) Systemic fungal diseases Ancylostoma duodenale ( cutaneous larva migrans) Leishmania spp Trypanosoma spp Measles Varicella zoster virus Herpes virus Human Immunodeficiency Virus Diabetes Long term Streoid therapy Neutropenia Liver cirrhosis Burns Alcoholism Organ transplantation Malnutrition Infectious disease (HIV and others) Extremes of age Long duration hospitalization Autoimmune diseases K V Ramana et al. Complicated Skin and Skin Structure Infections (cSSSI’s): A Comprehensive Review. American Journal of Medical and Biological Research, 2013, Vol. 1, No. 4, 159-164. doi:10.12691/ajmbr-1-4-9 © The Author(s) 2013. Published by Science and Education Publishing.