Teaching NeuroImages Neurology Resident and Fellow Section

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Presentation transcript:

Teaching NeuroImages Neurology Resident and Fellow Section Morgagni-Stewart-Morel- A metabolic craniopathy Teaching NeuroImages Neurology Resident and Fellow Section © 2013 American Academy of Neurology

Vignette 30-year-old woman 4 years slowly progressive history Memory loss, frontal headache, vertigo, depression Seizures (normal electroencephalogram) Previous history of endocrine disease Diabetes mellitus, obesity, hirsurtism and hypothyroidism Paternal family history suggests X-linked disease. A sagittal cranial T1-weighted MRI, CT scan and x-ray Evidenced bilateral thickening of the inner table of the frontal bone © 2013 American Academy of Neurology Brooks et al

Imaging © 2013 American Academy of Neurology Brooks et al Figure Title: Frontal bone craniopathy Figure Legend- Sagittal cranial T1-weighted MRI, CT scan and x-ray of head. © 2013 American Academy of Neurology Brooks et al

Morgagni-Stewart-Morel- A metabolic craniopathy Morgagni-Stewart-Morel syndrome Endocrine dysfunctions and neuropsychiatric symptoms Interpreted as components May correlate with the severity of the frontal hyperostosis May correlate with cortical atrophy Attention to this clinical-radiological correlation May help neurologists with the right diagnosis References: 1-Harding FE. Endocrinopathies associated with hyperostosis frontalis interna. Am J Med. 1949;6:329-35. 2-Attanasio F, Granziera S, Giantin V, Manzato E. Full penetrance of MorgagniStewart-Morel syndrome in a 75-year-old woman: case report and review of the literature. J Clin Endocrinol Metab. 2013;98:453-57. © 2013 American Academy of Neurology Brooks et al