Β-catenin knockout inhibits synovial sarcoma (SS) tumor growth in SYT–SSX2 transgenic mice. β-catenin knockout inhibits synovial sarcoma (SS) tumor growth.

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β-catenin knockout inhibits synovial sarcoma (SS) tumor growth in SYT–SSX2 transgenic mice. β-catenin knockout inhibits synovial sarcoma (SS) tumor growth in SYT–SSX2 transgenic mice. A, histogram represents total number of tumors in SG1 (SSM2+/Myf5-Cre+), SG2 (SSM2+/B-CATfl+/−/Myf5-Cre+), and SG3 (SSM2+/B-CATfl+/+/Myf5-Cre+) mice. B, dot plot tabulating number of tumors in the SG1, SG2, and SG3 mice, with median value bar. P values show significance of the difference between each pair of the experimental groups. C, left column, hematoxylin and eosin (H&E) staining of tumors (black arrows: blue nuclei) in the intercostal muscle (pink fibers) of SG1 (top row, SSM2+) and one of the three SG3 (bottom row, SSM2+/B-CATfl+/+) mice that developed tumors. Middle column, control mouse immunoglobulin G (IgG) immunostaining. Right column, β-catenin immunostaining. Control IgG and β-catenin stainings were conducted on serial tumor sections present on the same slide. Scale bars of all images are 99 μm. D, β-catenin immunofluorescent staining (red) in tumors from SG1 (SSM2+) and SG3 (SSM2+/B-CATfl+/+) mice. Mouse IgG served as negative control. DAPI (blue) stains nuclei. Merged blue and red images show β-catenin nuclear localization. Whitney Barham et al. Cancer Discovery 2013;3:1286-1301 ©2013 by American Association for Cancer Research