The Mysterious Motivational Functions of Mesolimbic Dopamine

Slides:

Advertisements

Similar presentations

Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala Marina A. Belova, Joseph J. Paton, Sara E. Morrison, C. Daniel.

Advertisements

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

NMDA Receptors in Dopaminergic Neurons Are Crucial for Habit Learning Lei Phillip Wang, Fei Li, Dong Wang, Kun Xie, Deheng Wang, Xiaoming Shen, Joe Z.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Canonical Microcircuits for Predictive Coding Andre M. Bastos, W. Martin Usrey, Rick A. Adams, George R. Mangun, Pascal Fries, Karl J. Friston Neuron Volume.

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons Mitsuko Watabe-Uchida, Lisa Zhu, Sachie K. Ogawa, Archana Vamanrao, Naoshige Uchida Neuron.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

Dissociable Medial Prefrontal Contributions to Judgments of Similar and Dissimilar Others Jason P. Mitchell, C. Neil Macrae, Mahzarin R. Banaji Neuron.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)

Rare Inherited Variation in Autism: Beginning to See the Forest and a Few Trees Jason L. Stein, Neelroop N. Parikshak, Daniel H. Geschwind Neuron Volume.

Neuronal Synchronization along the Dorsal Visual Pathway Reflects the Focus of Spatial Attention Markus Siegel, Tobias H. Donner, Robert Oostenveld, Pascal.

Building Better Models of Visual Cortical Receptive Fields

P.W. Kalivas, N. Volkow, J. Seamans Neuron

A Molecular Code for Imprinting Drug-Cue Associations

Kelly Howell, Oliver Hobert Neuron

Sparse Encoding of Natural Scents

Alexander Stein, Reinhard Jahn Neuron

Volume 69, Issue 4, Pages (February 2011)

Serotonin and the Orchestration of Energy Balance

Finding Gamma Neuron Volume 58, Issue 3, Pages (May 2008)

Pursuing the Link between Neurons and Behavior

The Hunger Genes: Pathways to Obesity

Parkinson’s Disease: A Thalamostriatal Rebalancing Act?

Michael Gliksberg, Gil Levkowitz Neuron

Can One Suppress Subliminal Words?

Oxytocin Mobilizes Midbrain Dopamine toward Sociality

Volume 84, Issue 3, Pages (November 2014)

A Code for Cross-Modal Working Memory

Pausing to Regroup: Thalamic Gating of Cortico-Basal Ganglia Networks

Volume 73, Issue 1, Pages 1-3 (January 2012)

Sparse Encoding of Natural Scents

Applying the Brakes: When to Stop Eating

Volume 68, Issue 2, Pages (October 2010)

Reinforcement Learning Signal Predicts Social Conformity

Recurrent Feedback Loops in Associative Learning

MicroRNAs in Memory Processing

Peter Kok, Janneke F.M. Jehee, Floris P. de Lange Neuron

Addiction: Pulling at the Neural Threads of Social Behaviors

The Strange Case of Aggression and the Brain

Dopamine: Burning the Candle at Both Ends

Reward Mechanisms in Obesity: New Insights and Future Directions

The Strange Case of Aggression and the Brain

Volume 91, Issue 6, Pages (September 2016)

Mark J. Buckley, Natasha Sigala Neuron

Brain Canada: One Brain One Community

Satb2 Stations Neurons along Reflex Arcs

Modeling Text-Based Requirements and their Relationship to Design

Dawn H. Loh, Takashi Kudo, Christopher S. Colwell Neuron

Cell Assemblies of the Superficial Cortex

Superior Colliculus Does Play Dice

Volume 57, Issue 5, Pages (March 2008)

Reward Mechanisms in Obesity: New Insights and Future Directions

A Synaptic Basis for GLP-1 Action in the Brain

Cartography of Serotonergic Circuits

Volume 58, Issue 4, Pages (May 2008)

The Dopamine D2 Receptor: New Surprises from an Old Friend

Brain Canada: One Brain One Community

Tasteless Food Reward Neuron

David Hubel and Torsten Wiesel

Nicolas Unsain, Philip A. Barker Neuron

Presentation transcript:

The Mysterious Motivational Functions of Mesolimbic Dopamine John D. Salamone, Mercè Correa Neuron Volume 76, Issue 3, Pages 470-485 (November 2012) DOI: 10.1016/j.neuron.2012.10.021 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 The Dependence of Some Aspects of Appetitive and Aversive Instrumental (i.e., Seeking) Behavior on Nucleus Accumbens DA Transmission The dependence of some aspects of appetitive and aversive instrumental (i.e., seeking) behavior on nucleus accumbens DA transmission. Salamone et al. (1991) noted that highly active instrumental behaviors elicited and supported by conditioned stimuli are very sensitive to disruption of accumbens DA transmission. Koob et al. (1978) reported that neurotoxic depletions of accumbens DA decreased behavioral activation but actually tended to increase food consumption. Nicola (2010) emphasized the importance of accumbens DA for flexible approach to the reinforcing stimulus. Neuron 2012 76, 470-485DOI: (10.1016/j.neuron.2012.10.021) Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 2 Impact of Dopaminergic Manipulations on Motivated Behavior This figure illustrates that there are multiple dimensions that are relevant for understanding the impact of DAergic manipulations on motivated behavior. Interference with accumbens DA transmission is very likely to disrupt vigorous or effortful instrumental behaviors that are instigated or supported by conditioned stimuli. In contrast, consummatory behaviors such as food intake, which involves direct interaction with a primary motivational stimulus, as well as aversive behaviors induced by a primary aversive stimulus (e.g., escape), tend to be less easily disrupted by DAergic manipulations (see references in text). Although these factors are depicted as distinct dimensions, they also interact. For example, instrumental behaviors are generally instigated by conditioned stimuli, and conditioned stimuli also have activating properties. Neuron 2012 76, 470-485DOI: (10.1016/j.neuron.2012.10.021) Copyright © 2012 Elsevier Inc. Terms and Conditions