SAHA-induced polyploid cells underwent senescence.

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SAHA-induced polyploid cells underwent senescence. SAHA-induced polyploid cells underwent senescence. A, HCT116 p21−/− cells cultured without 0.8 μmol/L SAHA for 3 days were negative for SA-β-gal. B-C, most HCT116 p21−/− cells cultured with 0.8 μmol/L SAHA for 3 days became polyploid cells (B), but only few of them were positive for SA-β-gal (C). D-E, most HCT116 p21−/− cells cultured with 0.8 μmol/L SAHA for 5 days and without SAHA for another 3 days became polyploid cells with more nuclei, large size and wide and fat cytoplasm (D), and virtually all polyploid cells were positive for SA-β-gal (E). F, percentage of SA-β-gal-positive polyploid cells in HCT116 p21+/+ and p21−/− cells cultured with 0.8 μmol/L SAHA, and p53+/+ and p53−/− cells cultured with 2 μmol/L SAHA for 5 days. Wei-Sheng Xu et al. Cancer Res 2005;65:7832-7839 ©2005 by American Association for Cancer Research