ALD in an 8-year-old patient.

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Presentation transcript:

ALD in an 8-year-old patient. ALD in an 8-year-old patient. Axial-view spin-echo (2500/30) image shows T2 prolongation in the callosal splenium and forceps major, regions where high concentrations of ALD protein are expressed.fig 8. MLD in a 2-year-old patient. Axial-view spin-echo (2500/80) image shows T2 prolongation, representing loss of myelin, in the central hemispheric white matter. The subcortical white matter is relatively spared. The radial stripes extending through the hemispheres are characteristic of the MR imaging appearance in this disorder.fig 9. Pelizaeus-Merzbacher disease in a 5-year-old patient. Axial-view spin-echo (600/15) image shows a paucity of myelin, with hyperintensity only in the internal capsules and optic radiations (compare with fig 4).fig 10. MS. Parasagittal fast spin-echo (3500/102) image shows differing degrees of hyperintensity in the large tumefactive plaque in the posterior frontal lobe, possibly representing different degrees of myelin and axonal destruction. A. James Barkovich AJNR Am J Neuroradiol 2000;21:1099-1109 ©2000 by American Society of Neuroradiology