Gene expression in the PFC of mice with an inducible neuron-specific bdnf knock-out in embryogenesis. Gene expression in the PFC of mice with an inducible.

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Gene expression in the PFC of mice with an inducible neuron-specific bdnf knock-out in embryogenesis. Gene expression in the PFC of mice with an inducible neuron-specific bdnf knock-out in embryogenesis. Representative autoradiograms (A-H) illustrating the expression of BDNF (A, B), and TrkB (C, D), GAD67 (E, F), and PV (G, H) mRNAs in a control mouse (A, C, E, G) and a mouse with embryonic bdnf knock-out (B, D, F, H) at 5 month of age are shown. The densities of hybridization signals are presented in a pseudocolor manner according to the calibration scales (right) for each mRNA. Note that BDNF mRNA expression was dramatically decreased in the knock-out mouse (B) compared with the control (A). GAD67 (E, F) and PV (G, H) mRNA expression levels appear to be similar between knock-out and control mice, whereas the expression level of TrkB mRNA is higher in the knock-out mouse (D) than the control mouse (C). The arrowheads in C and D indicate the quantified regions in the PFC in all sections from each mouse. Scale bar (in H), 1 mm. I-L, Mean ± SD expression levels of BDNF (I), TrkB (J), GAD67 (K), and PV (L) mRNAs in control and embryonic bdnf knock-out mice. Although BDNF mRNA expression levels are significantly decreased by 80% in embryonic knock-out mice (I), the expression levels of both GAD67 and PV mRNAs are unchanged (K, L). The expression level of TrkB mRNA is increased by 20% in embryonic knock-out mice with marginal significance. Takanori Hashimoto et al. J. Neurosci. 2005;25:372-383 ©2005 by Society for Neuroscience