Fig. 4 S. elongatus therapy does not elicit a pathologic immune response nor persist in tissue long-term. S. elongatus therapy does not elicit a pathologic.

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Fig. 4 S. elongatus therapy does not elicit a pathologic immune response nor persist in tissue long-term. S. elongatus therapy does not elicit a pathologic immune response nor persist in tissue long-term. (A) Flow cytometry of blood at 0, 16, 40, and 88 hours after intravenous administration of saline (n = 4) or S. elongatus (n = 4), demonstrating no difference in CD8+ T cell and CD19+ B cell frequencies. PE, phycoerythrin; FITC, fluorescein isothiocyanate. (B) No differences in peripheral CD4+ T cell frequencies at 0, 1, 2, and 7 days were observed (means ± SD). (C and D) Immunohistochemistry of heart sections at 1 hour after injection (C) and 24 hours after injection (D), demonstrating marked reduction of S. elongatus present in the tissue. (E) Representative hematoxylin and eosin–stained heart section revealing no abscess at 4 weeks after therapy. (F and G) Immunohistochemistry of heart sections at 4 weeks, illustrating no evidence of retained S. elongatus. All data reported as means ± SEM. DAPI, 4′,6-diamidino-2-phenylindole. Jeffrey E. Cohen et al. Sci Adv 2017;3:e1603078 Copyright © 2017, The Authors